Bis-PEG4-sulfonic acid
CAS No.: 1807539-08-7
Cat No.: BP-501576
Purity: ≥95%
4.5 
Bis-PEG4-sulfonic acid is a bifunctional, PEG-based linker bearing two sulfonic acid termini, providing a hydrophilic, water-compatible scaffold with a defined polyethylene glycol chain length on each arm. Its structural features—polyether segments for conformational flexibility and terminal sulfonate groups for strong anionic character—make it well suited for constructing PROTACs and related targeted degradation conjugates where solubility and linker behavior are critical. In PROTAC design, this type of linker can spatially separate the ligand-binding elements (e.g., a target-recruiting warhead and an E3 ligase-binding moiety) while maintaining sufficient flexibility to enable productive ternary complex formation. The sulfonate groups can also support aqueous handling and reduce nonspecific aggregation, improving experimental robustness in biochemical and cell-based assays. As a modular linker component, it helps researchers systematically tune linker length, polarity, and geometry to optimize degradation potency and selectivity.
Structure of 1807539-08-7
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Bis-PEG4-sulfonic acid is a PEG-based, water-compatible PROTAC linker building block designed to provide solubility, conformational flexibility, and reliable spacing between targeting ligands. Its sulfonic acid functionality enables strong ionic interactions and improved handling in aqueous coupling workflows, supporting efficient assembly of degraders for targeted protein degradation studies. The structure and reactivity considerations for PROTAC synthesis are described in detail below.
Structure: The linker is a bis-PEG scaffold bearing terminal sulfonic acid groups, providing flexible ether-rich connectivity and strongly polar, ionizable functionalities. It contains multiple ether linkages and sulfonate-bearing acidic sites, yielding high hydrophilicity and stable, non-volatile behavior under typical synthetic conditions.
Reactivity: For PROTAC construction, the sulfonic acid termini are commonly leveraged through activation to form reactive sulfonate derivatives or through coupling strategies that tolerate aqueous or mixed-solvent environments. Suitable approaches include acid activation followed by nucleophilic substitution with appropriately functionalized ligand handles, often using standard coupling reagents and base-mediated conditions to promote efficient bond formation while minimizing hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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