Boc-NH-PEG15-azide
Cat No.: BP-502006
4.5 
Boc-NH-PEG15-azide is a Boc-protected amino-terminated polyethylene glycol linker bearing a terminal azide functionality, enabling modular conjugation in PROTAC and targeted protein degradation workflows. Structurally, it consists of a linear PEG chain of extended length that provides conformational flexibility and aqueous solubility, while the azide group serves as a bioorthogonal handle for copper-free or copper-catalyzed azide–alkyne cycloaddition (“click”) to install the linker between a ligand warhead and an E3 ligase–recruiting moiety. The Boc-protected amine allows controlled coupling chemistry during PROTAC assembly, minimizing side reactions until deprotection or activation is performed. In targeted degradation research, PEG-based spacers can reduce steric clashes and help tune the effective distance and orientation required for ternary complex formation, which is critical for efficient ubiquitination and downstream proteasomal degradation. This linker is therefore valuable for constructing libraries of degraders with systematic linker length and attachment-site variation.
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* For research and manufacturing use only. Not for human or clinical use.
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Boc-NH-PEG15-azide is a PEG-based heterobifunctional linker designed for PROTAC assembly, combining an azide handle for bioorthogonal conjugation with a protected amine for controlled coupling strategies. Its flexible poly(ethylene glycol) scaffold promotes productive linker length and conformational adaptability, which can improve ternary complex formation and targeted protein degradation performance. The detailed structural and synthetic considerations for using this molecule in PROTAC workflows are provided below.
Structure: The linker comprises a Boc-protected amino terminus connected to a polyethylene glycol chain and terminated by an azide group. It contains carbamate and ether linkages along a flexible, highly solvated PEG backbone, with a polar, water-compatible character that supports solubility and reduced nonspecific interactions.
Reactivity: The azide functionality enables copper-catalyzed azide–alkyne cycloaddition or strain-promoted azide–alkyne cycloaddition, depending on the partner warhead and desired conditions. The Boc group can be removed under standard acid-mediated deprotection to reveal a primary amine for amide or urea-forming couplings. Typical PROTAC linker conjugations are performed in compatible organic/aqueous mixtures using coupling reagents such as carbodiimides, with careful control of pH and temperature to preserve sensitive functional groups.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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