Boc-NHCH2CH2-PEG1-azide
CAS No.: 176220-30-7
Cat No.: BP-501610
4.5 
Boc-NHCH2CH2-PEG1-azide is a protected, short polyethylene glycol (PEG) linker bearing a Boc-protected amine, a two-carbon spacer, and a terminal azide handle. Structurally, it combines a hydrophilic PEG segment with an orthogonally reactive azide group, enabling chemists to connect PROTAC building blocks through bioorthogonal azide–alkyne cycloaddition (CuAAC or SPAAC) or related azide conjugation strategies. In PROTAC design, such linkers are used to tune the effective distance and conformational flexibility between the ligand that recruits an E3 ligase and the target-binding moiety, which can strongly influence ternary complex formation and degradation potency. The Boc protection supports controlled coupling during synthesis and subsequent deprotection when required for downstream assembly. This linker is therefore valuable for constructing modular targeted degradation probes, facilitating rapid synthesis of linker variants and systematic structure–activity relationship studies.
Structure of 176220-30-7
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This Boc-protected amino-PEG azide linker is designed for efficient assembly of PROTACs by providing a chemically addressable azide handle alongside a protected amine for controlled conjugation. Its polyethylene glycol segment supports favorable solubility and conformational flexibility, which can improve linker compatibility in targeted protein degradation constructs. The structural features enable orthogonal coupling strategies, and the subsequent sections describe its structure and practical reactivity considerations in PROTAC synthesis.
Structure: The molecule contains a Boc-protected amino terminus, an ethylene spacer, and a short polyethylene glycol segment terminating in an azide functional group. It features carbamate and ether linkages, along with a primary azide for bioorthogonal reactivity. Overall polarity is enhanced by the PEG chain, supporting aqueous compatibility.
Reactivity: The azide is suitable for copper-free or copper-catalyzed azide–alkyne cycloaddition to attach diverse targeting or warhead modules under mild conditions. The Boc group is typically stable during many coupling steps but can be removed using standard acidolysis to reveal the amine for subsequent amide or urea-forming reactions. Common solvents include polar aprotic media and buffered aqueous mixtures, depending on the coupling chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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