C-NH-Boc-C-Bis-(C-PEG1-Boc)
CAS No.: 1807503-91-8
Cat No.: BP-501432
4.5 
C-NH-Boc-C-Bis-(C-PEG1-Boc) is a protected, bifunctional PROTAC linker building block featuring one Boc-protected amine and two short arms terminated as tert-butyl ester-protected carboxylic acids. The presence of PEG segments provides conformational flexibility and improves aqueous solubility, while the Boc group protects the amine and the two tert-butyl esters protect the carboxylic acids during assembly, enabling controlled deprotection or coupling steps under standard synthetic workflows. In PROTAC design, such linkers are used to spatially separate a target-binding ligand from an E3 ligase recruiter, tuning the effective distance and relative orientation required for formation of a productive ternary complex. By mediating this conjugation geometry and reducing unfavorable intramolecular interactions, the linker can help optimize degradation efficiency and selectivity in targeted protein degradation experiments. This reagent is therefore valuable for constructing modular PROTACs and for systematic structure–activity studies where linker length, polarity, and protection state must be experimentally controlled.
Structure of 1807503-91-8
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This PROTAC linker reagent, C-NH-Boc-C-Bis-(C-PEG1-Boc), is designed to provide controlled connectivity between targeting ligands and to support efficient formation of degraders. Its protected amine functionality enables stepwise assembly under conditions commonly used in PROTAC synthesis, while the PEG-containing spacer can help tune solubility and conformational flexibility. The sections below describe its structure-related features and practical reactivity considerations for experimental linker-to-ligand coupling and final PROTAC construction.
Structure: The molecule contains one Boc-protected amine together with two PEG-containing arms terminating in carboxylic acids protected as tert-butyl esters. It features one Boc carbamate, two tert-butyl ester groups, and ether linkages within the PEG segments, supporting stable handling and modular assembly.
Reactivity: The Boc-protected amine can be deprotected to reveal an amine, while the two tert-butyl esters can be cleaved to reveal carboxylic acids for stepwise amide/urea-forming bond construction. Deprotection conditions should be selected to manage both the Boc carbamate and the tert-butyl esters, followed by coupling using standard activating reagents in polar aprotic solvents. Mechanistically, deprotection can generate a reactive amine and/or carboxylic acid handles for subsequent bond formation to targeting ligands, enabling controlled PROTAC synthesis workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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