Cbz-N-amido-PEG20-acid
Cat No.: BP-501741
4.5 
Cbz-N-amido-PEG20-acid is a polyethylene glycol–based PROTAC linker bearing a Cbz-protected amide terminus and a terminal carboxylic acid. Structurally, it provides a long, flexible hydrophilic chain (PEG20) that can spatially separate a ligand-bearing “warhead” from an E3-recruiting moiety while reducing steric clashes and often improving solubility and bioconjugation practicality. The carboxylic acid enables standard linker–to–ligand coupling chemistries (e.g., amide bond formation) to connect this spacer to functional groups on other PROTAC components, whereas the N-amido functionality supports stable conjugation strategies and can be compatible with common synthetic workflows. In targeted protein degradation research, such PEG spacers are widely used to tune effective linker length and conformational freedom, which can strongly influence ternary complex formation and degradation potency. This product is therefore valuable for systematic PROTAC optimization, facilitating reproducible synthesis of linker variants for structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker, Cbz-N-amido-PEG20-acid, is designed to provide a hydrophilic, flexible spacer that supports effective spatial alignment between a ligand-bearing warhead and an E3-recruiting module. Its PEG-based architecture helps tune solubility and conformational freedom for targeted protein degradation conjugation workflows. The detailed Structure and Reactivity parameters are provided below.
Structure: The linker combines a benzyloxycarbonyl-protected amino group with a long polyethylene glycol chain terminating in a carboxylic acid. It contains a Cbz carbamate, a terminal carboxylic acid, and ether linkages, with a flexible PEG backbone that enhances aqueous compatibility during conjugation.
Reactivity: The terminal carboxylic acid enables standard amide-bond formation to connect to amine-bearing PROTAC components, typically via coupling chemistries used for carboxylic acids. The Cbz-protected nitrogen can be deprotected under hydrogenolysis conditions to reveal a free amine for subsequent coupling. Solvents such as common organic coupling media and aqueous-compatible buffers are selected to maintain solubility and reaction efficiency, following established PROTAC linker conjugation practices.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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