CHO-Ph-CONH-PEG2-amine
CAS No.: 2055013-56-2
Cat No.: BP-501489
Purity: ≥95%
4.5 
CHO-Ph-CONH-PEG2-amine is a short, amine-terminated polyethylene glycol (PEG) linker bearing a benzamide connection and an aldehyde-derived “CHO” handle for controlled functionalization. Structurally, it provides a flexible two–ethylene glycol unit spacer that can be used to tune solubility, reduce steric constraints, and position a reactive group for subsequent conjugation. In PROTAC design, such linkers are used to connect a targeting ligand (e.g., for an E3 ligase recruiter) to a second binding module (e.g., a target protein binder) while maintaining productive geometry for ternary complex formation. The terminal amine enables coupling to activated carboxylates, activated carbonyls, or other electrophiles, whereas the aldehyde functionality supports formation of reversible or derivatizable linkages depending on the chosen chemistry. This product is valuable for constructing small, modular degraders and for rapid linker optimization in targeted protein degradation workflows, where linker length and attachment chemistry strongly influence degradation potency and selectivity.
Structure of 2055013-56-2
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This PROTAC linker, CHO-Ph-CONH-PEG2-amine, is designed to connect a warhead-bearing ligand to an E3-recruiting module through a PEG-based spacer, supporting productive ternary complex formation. Its ether-rich, flexible architecture can improve solubility and reduce steric constraints, while the terminal amine enables straightforward conjugation strategies. The detailed structural and synthetic considerations are provided below for researchers optimizing linker installation and PROTAC assembly.
Structure: The linker contains an aromatic phenyl core linked to a carbonyl amide (–CONH–), followed by a short polyethylene glycol segment that provides conformational flexibility. An amine terminus enables nucleophilic coupling, while ether linkages contribute hydrophilicity and favorable aqueous compatibility.
Reactivity: The terminal amine is suitable for forming amide or urea linkages with activated carboxylic acids or carbonyl electrophiles commonly used in PROTAC synthesis. Typical approaches employ coupling reagents for amide bond formation, with polar aprotic solvents and mild base to maintain functional-group compatibility. Mechanistically, nucleophilic acyl substitution or related condensation pathways connect the linker to complementary reactive handles on target ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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