Mal-PEG2-NH2
CAS No.: 660843-22-1
Cat No.: BP-501537
4.5 
Mal-PEG2-NH2 is a short, heterobifunctional polyethylene glycol linker bearing a terminal maleimide group and a primary amine. Structurally, it combines a maleimide “reactive handle” with a two-ethylene-oxide PEG spacer that provides aqueous solubility and reduces nonspecific interactions, while the terminal amine enables further coupling or derivatization. In PROTAC and targeted protein degradation workflows, the maleimide moiety is commonly used to form stable thioether bonds with cysteine-containing ligands (e.g., engineered or naturally accessible Cys residues on binding domains or intermediate constructs), thereby enabling efficient conjugation under mild conditions. The PEG spacer helps maintain productive geometry and improves the solubility and handling of multicomponent degraders. This linker is valuable for assembling modular PROTAC architectures, facilitating stepwise synthesis of conjugates, and optimizing linker length and hydrophilicity to support robust ternary complex formation and degradation efficacy.
Structure of 660843-22-1
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Mal-PEG2-NH2 is a bifunctional PEG-based linker designed for constructing PROTACs through efficient conjugation to targeting ligands and subsequent assembly into degraders. Its PEG spacer supports solubility and conformational flexibility, while the maleimide handle enables selective coupling to thiol-containing biomolecules or ligand intermediates. The result is a practical, modular platform for researchers optimizing linker length, attachment chemistry, and overall PROTAC performance; the following points describe its structure and reactivity in detail.
Structure: Mal-PEG2-NH2 comprises a maleimide electrophile linked to a short polyethylene glycol spacer terminating in a primary amine. The maleimide features an activated alkene within a cyclic imide, while the PEG segment provides ether-rich flexibility. The molecule is polar and water-compatible, facilitating handling during bioconjugation workflows.
Reactivity: The maleimide group undergoes thiol–maleimide conjugation via a Michael-type addition under mildly basic aqueous conditions, forming a stable thioether linkage. Thiols are typically generated or introduced from cysteine-containing ligands or protected thiol precursors, with careful control of pH to favor selective coupling. Common solvents include aqueous buffers with optional cosolvents; catalysts are generally unnecessary, but reducing agents and competing nucleophiles should be managed to preserve reactivity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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