DBCO-PEG13-DBCO
Cat No.: BP-501891
Purity: 98%
4.5 
DBCO-PEG13-DBCO is a homobifunctional polyethylene glycol linker bearing two dibenzocyclooctyne (DBCO) groups at the termini of a long, flexible PEG chain. Structurally, it provides a hydrophilic, conformationally mobile spacer that positions the two strained cyclooctyne moieties for efficient strain-promoted azide–alkyne cycloaddition (SPAAC) without added copper. In PROTAC and targeted degradation workflows, this linker is used to conjugate azide-functionalized ligands (e.g., an E3 ligase binder or a target-binding moiety) to DBCO-functionalized partners, enabling modular assembly of degraders with controlled inter-component spacing and reduced steric interference. The PEG backbone can also improve solubility and decrease nonspecific aggregation, which is advantageous for iterative synthesis and structure–activity studies. Overall, DBCO-PEG13-DBCO supports rapid, catalyst-free coupling and rational linker optimization for mechanistic and SAR investigations in targeted protein degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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This DBCO-PEG13-DBCO linker is designed for modular PROTAC assembly by enabling efficient, bioorthogonal conjugation through strained cyclooctyne chemistry. Its PEG-based spacer promotes solubility and conformational flexibility, supporting productive ternary complex formation in targeted protein degradation workflows. The molecule’s dual reactive termini allow orthogonal coupling to complementary PROTAC components, facilitating streamlined synthesis and systematic optimization. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises two DBCO (dibenzocyclooctyne) moieties connected by a polyethylene glycol spacer. It contains strained alkyne functionality characteristic of DBCO, ether linkages within the PEG chain, and aromatic rings that stabilize the cyclooctyne. These features support aqueous compatibility and stable, high-yield conjugation.
Reactivity: DBCO groups undergo strain-promoted azide–alkyne cycloaddition with azide-functional partners under mild, catalyst-free conditions. For PROTAC construction, conjugation is typically performed in biocompatible solvents such as aqueous buffers or mixed organic/aqueous systems, with pH and ionic strength chosen to preserve azide and protein-reactive handles. The reaction proceeds via cycloaddition to form a stable triazole linkage without requiring copper catalysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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