DBCO-PEG9-NH-Boc
Cat No.: BP-501846
Purity: 98%
4.5 
DBCO-PEG9-NH-Boc is a bifunctional, PEG-based PROTAC linker featuring a cyclooctyne (DBCO) for copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) and a terminal protected amine (Boc) that can be used for subsequent coupling or deprotection. The PEG segment provides a flexible, hydrophilic spacer that helps reduce steric hindrance and improves effective reach between the two conjugation partners, which is critical when assembling multi-component targeted degradation constructs. In PROTAC design workflows, the DBCO handle enables rapid, bioorthogonal attachment to azide-functional ligands or handles under mild conditions, while the Boc-protected nitrogen offers an orthogonal functional group for controlled derivatization (e.g., installing additional linkers, attaching solubilizing motifs, or enabling stepwise synthesis). This combination supports modular assembly, reproducible conjugation chemistry, and optimization of linker length and geometry to tune ternary complex formation and degradation efficiency in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This DBCO-PEG9-NH-Boc linker is designed for efficient, modular assembly of PROTACs that rely on copper-free bioorthogonal conjugation. It combines a strained cyclooctyne (DBCO) handle with a PEG spacer to enhance solubility and reduce steric constraints, while the protected amine enables controlled downstream functionalization. The molecule is typically used to connect targeting ligands and enable reliable formation of conjugates under mild conditions; detailed structural and reactivity considerations are provided below.
Structure: The linker contains a DBCO cyclooctyne moiety for strain-promoted azide–alkyne cycloaddition, connected through a polyethylene glycol chain to a secondary amine that is Boc-protected. It features ether-rich PEG segments, an N–C Boc carbamate functionality, and a strained alkyne suitable for rapid click-type coupling.
Reactivity: For PROTAC construction, the DBCO group reacts with azide-bearing partners via copper-free strain-promoted azide–alkyne cycloaddition, typically performed in polar organic solvents or mixed aqueous systems at mild temperatures. The Boc group can be removed under standard acid-mediated deprotection conditions to reveal an amine for subsequent amide or urea coupling steps, allowing sequential conjugation and purification of intermediates before final assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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