Diketone-PEG11-Diketone
Cat No.: BP-501910
4.5 
Diketone-PEG11-Diketone is a heterobifunctional PEG-based linker featuring two terminal diketone motifs and a long, flexible poly(ethylene glycol) chain that provides aqueous solubility and conformational spacing. Structurally, the diketone end groups can coordinate metal ions and/or participate in reversible chelation-type interactions, while the PEG segment acts as a hydrophilic spacer that reduces steric interference between the two conjugated partners. In PROTAC and targeted protein degradation designs, such linkers are used to connect an E3 ligase–binding ligand to a target-binding ligand while maintaining sufficient distance and mobility for productive ternary complex formation. The dual diketone functionality can also enable controlled conjugation strategies to metal-chelated intermediates or to diketone-reactive platforms, facilitating modular assembly of degradation constructs. Overall, this linker is valuable for researchers seeking robust, water-compatible PROTAC architectures that balance flexibility, solubility, and effective inter-ligand positioning to support degradation efficacy.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This Diketone-PEG11-Diketone linker is designed to support PROTAC assembly by providing a flexible, hydrophilic polyethylene glycol (PEG) spacer that can tune linker length and improve solubility in typical organic–aqueous workflows. The central diketone motifs enable robust, chemistry-compatible attachment strategies to enable targeted protein degradation constructs. Detailed structural and reactivity considerations for PROTAC synthesis are provided below.
Structure: The linker comprises two diketone-bearing termini connected through an extended PEG chain, yielding a flexible, ether-rich scaffold. It contains carbonyl functionalities characteristic of diketones, along with multiple ether linkages that impart polarity, conformational mobility, and improved aqueous compatibility relevant to PROTAC conjugation chemistry.
Reactivity: Diketone-containing linkers are commonly used in PROTAC build schemes that rely on carbonyl reactivity for selective conjugation, including formation of reversible adducts and subsequent stabilization steps under controlled conditions. Linker coupling is typically performed using standard amide/imine-type compatible conditions, with inert atmosphere where required, and solvents selected to balance diketone reactivity and solubility. Reaction progress is monitored by analytical methods, and purification is performed to remove unreacted starting materials.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
