DNP-PEG4-OH
CAS No.: 1807520-99-5
Cat No.: BP-501181
Purity: ≥95%
4.5 
DNP-PEG4-OH is a heterobifunctional polyethylene glycol (PEG) linker bearing a dinitrophenyl (DNP) recognition/tagging group and a terminal hydroxyl group, providing a short, flexible four–ethylene glycol unit spacer. The PEG segment imparts aqueous solubility and conformational mobility, helping to reduce steric interference between the two conjugated partners in a PROTAC or related targeted degradation construct. In targeted protein degradation workflows, the DNP moiety is widely used for selective capture of DNP-binding ligands or engineered systems through well-characterized DNP–receptor interactions, enabling controlled proximity between an affinity module and a recruited E3 ligase or other functional component. The terminal hydroxyl group serves as a convenient functional handle for further derivatization (e.g., coupling to electrophiles or activation chemistries) to assemble multi-component degraders. Overall, DNP-PEG4-OH is valuable for researchers seeking modular, water-compatible linker architectures to tune conjugation geometry and improve the efficiency and reproducibility of degradation assays.
Structure of 1807520-99-5
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DNP-PEG4-OH is a polyethylene glycol-based PROTAC linker building block designed to provide solubility, conformational flexibility, and a functional handle for conjugation to targeting ligands. Its PEG architecture helps tune linker length and hydrophilicity, which can improve productive ternary complex formation and overall degradation performance in targeted protein degradation workflows. The following sections describe the structure and reactivity considerations for constructing PROTACs using this linker in detail below.
Structure: DNP-PEG4-OH contains an ethylene glycol repeat unit segment terminated by a hydroxyl group, providing a flexible, hydrophilic chain. The molecule features ether linkages within the PEG backbone and a terminal alcohol suitable for further functionalization, with physicochemical behavior dominated by hydrogen-bonding and solvent compatibility.
Reactivity: The terminal hydroxyl enables standard linker-to-ligand coupling strategies typically used in PROTAC synthesis, including activation to form leaving groups followed by nucleophilic substitution or ester/ether formation. Common approaches employ carbodiimide-mediated esterification or halide/activated-carbonyl intermediates under mild, anhydrous conditions. Solvents such as polar aprotic media are frequently used to maintain solubility, and reaction temperatures are selected to preserve ligand integrity while promoting efficient conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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