Dox-Ph-PEG1-Cl
CAS No.: 773095-86-6
Cat No.: BP-501586
4.5 
Dox-Ph-PEG1-Cl is a PEG-based PROTAC linker featuring a 1,3-dioxolane-substituted phenyl unit connected to a short ethoxy segment terminated with a reactive chloride (–Cl) for subsequent conjugation chemistry. Structurally, the linker combines an aromatic phenyl unit that can help position the ligand and modulate local sterics with a brief PEG chain that improves aqueous solubility and reduces nonproductive aggregation. In PROTAC design, such linkers are used to spatially tune the relative orientation and effective reach between the conjugated ligand and the recruited E3 ligase component, thereby influencing formation of the ternary complex and the efficiency of targeted protein degradation. This product is valuable for researchers optimizing linker length and attachment geometry during iterative synthesis and for probing how short PEG segments and aromatic spacers affect degradation potency and selectivity in cellular assays.
Structure of 773095-86-6
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Dox-Ph-PEG1-Cl is a PEG-based chloro-functional linker designed for efficient conjugation in PROTAC architectures. Its ether-rich polyethylene glycol segment provides conformational flexibility and improved aqueous compatibility, while the aryl and reactive chloro handle enable targeted attachment to ligands. This linker supports modular synthesis of PROTACs and can be used to assemble degraders where controlled connectivity and solubility are important. Detailed structural and synthetic considerations are provided below.
Structure: The linker comprises a PEG chain connected to an aryl group and terminated with a chloro leaving group. It contains ether linkages characteristic of polyethylene glycol segments, along with aromatic carbon–carbon framework connectivity. Overall, it is expected to show enhanced hydrophilicity and reduced aggregation relative to purely hydrocarbon linkers.
Reactivity: The chloro terminus is suitable for nucleophilic substitution reactions commonly used to connect PROTAC ligands bearing appropriate nucleophiles. Typical approaches employ base-assisted conditions in polar aprotic solvents to promote substitution, with the reaction proceeding via an SN-type mechanism depending on substrate electronics. Selection of base strength and temperature should be guided by ligand stability and the nucleophile’s reactivity, while avoiding conditions that may induce side reactions on sensitive functional groups.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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