DSPE-PEG46-Folate
Cat No.: BP-501826
4.5 
DSPE-PEG46-Folate is an amphiphilic, lipid–polymer conjugate composed of the phospholipid DSPE linked to a long polyethylene glycol chain terminated with folate. Structurally, it provides a hydrophobic anchor for membrane association or lipid nanoparticle formulation, while the PEG spacer confers colloidal stability and reduces nonspecific protein adsorption. The folate ligand enables selective binding to folate receptors that are overexpressed on many cancer cell types, thereby promoting receptor-mediated uptake. In targeted protein degradation research, this linker is valuable as a modular “delivery” component to enhance cellular internalization of PROTACs or other targeted degraders, improving effective intracellular exposure without directly altering the degrader’s binding motifs. Its PEGylated, lipid-anchored architecture supports formulation into nanoscale carriers and can be used to compare delivery efficiency across folate-dependent and folate-independent experimental conditions.
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* For research and manufacturing use only. Not for human or clinical use.
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DSPE-PEG46-Folate is a PEGylated phospholipid linker designed to support targeted protein degradation workflows by enabling efficient conjugation and presentation of targeting ligands in PROTAC-related construct assembly. Its amphiphilic phospholipid anchor supports stable membrane or lipid-mediated organization, while the PEG spacer improves solubility and reduces nonspecific interactions. Folate provides a widely used targeting handle for receptor-mediated uptake, and the subsequent sections describe its structure and practical reactivity considerations in detail below.
Structure: The linker comprises a phospholipid (DSPE) headgroup covalently linked to a long polyethylene glycol chain, terminating in a folate-derived targeting moiety. It contains ester and ether linkages within the lipid and PEG segments, along with heteroatom-rich functional groups that support conjugation chemistry. The overall architecture is amphiphilic and highly water-compatible due to PEG.
Reactivity: DSPE-PEG-folate is typically employed in PROTAC-adjacent conjugation schemes where the PEG terminus or folate-associated functionality is functionalized for coupling to biomolecular ligands. Conjugation commonly relies on amide-forming or thiol-reactive strategies, using standard coupling reagents and controlled pH to preserve protein-binding activity. Solvent systems that maintain colloidal stability of PEGylated lipids (often aqueous buffer with compatible co-solvents) are preferred; reactions are generally performed under inert or low-oxidation conditions to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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