Lipoamido-PEG3-azide
CAS No.: 890016-39-4
Cat No.: BP-501094
Purity: ≥95%
4.5 
Lipoamido-PEG3-azide is a heterobifunctional PEG-based linker featuring a lipophilic lipoamide (lipoamido) terminus, a short three-unit ethylene glycol spacer, and a terminal azide for bioorthogonal conjugation. The PEG3 segment provides aqueous solubility and conformational flexibility, helping minimize steric interference between the two PROTAC-relevant fragments. In PROTAC design, the azide handle enables efficient attachment via azide–alkyne cycloaddition (CuAAC or strain-promoted variants) or related click chemistries to install the linker onto a targeting ligand or E3 ligase-binding moiety, while the lipoamido end can be used to incorporate hydrophobic character or to support attachment strategies compatible with amide-containing intermediates. This linker is valuable for constructing modular targeted protein degradation probes where controlled spacing and reliable chemoselective coupling are required to preserve binding and promote productive ternary complex formation.
Structure of 890016-39-4
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Lipoamido-PEG3-azide is a PEG-based, functionalized linker designed for modular assembly of PROTACs via azide-compatible chemistries. Its polyethylene glycol segment provides conformational flexibility and improved solubility, while the azide handle enables efficient conjugation to complementary partners under well-established click-type conditions. This product supports the systematic construction of targeted protein degradation reagents, and the following sections describe its structure and practical reactivity considerations in detail below.
Structure: The linker comprises a lipoamido motif connected to a short polyethylene glycol chain terminating in an azide group. It contains amide (lipoamido) and ether linkages typical of PEG, providing polarity and hydrogen-bonding capacity, with an azide functional group suitable for bioorthogonal conjugation.
Reactivity: The azide functionality is commonly used in copper-catalyzed or copper-free azide–alkyne cycloaddition to form stable triazole linkages with alkyne-bearing warheads or handles. Suitable conditions generally involve compatible solvents that dissolve both partners and minimize azide decomposition, with catalysts and ligands selected to balance reaction rate and protein/functional-group tolerance. Reaction progress is typically monitored by analytical methods appropriate for PROTAC intermediates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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