Fmoc-NH-PEG16-CH2CH2COOH
Cat No.: BP-502025
4.5 
Fmoc-NH-PEG16-CH2CH2COOH is a heterobifunctional polyethylene glycol (PEG) linker featuring an N-terminal Fmoc-protected amine for solid-phase or amine-coupling workflows, a long PEG spacer that provides aqueous solubility and conformational flexibility, and a terminal carboxylic acid for subsequent conjugation. Structurally, it is an amide-linked PEG chain of extended length terminated with a two-carbon spacer to a free acid, enabling reliable attachment to targeting ligands or E3-recruiting modules through standard amide-bond formation. In PROTAC design, such PEG linkers help tune the effective distance and relative orientation between the two binding moieties, often improving ternary complex formation while reducing steric clashes and aggregation. The terminal carboxyl group also facilitates modular synthesis, allowing researchers to generate PROTACs with controlled linker placement and to systematically evaluate how linker length and flexibility impact degradation potency and selectivity in targeted protein degradation studies.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Fmoc-NH-PEG16-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker building block designed to provide a flexible, hydrophilic spacer between a ligand and a reactive functional group for subsequent conjugation. Its Fmoc-protected amine enables controlled stepwise assembly, while the terminal carboxylic acid supports reliable coupling chemistry. This linker is commonly used to tune linker length, solubility, and conformational freedom in targeted protein degradation workflows; detailed structural and reactivity considerations are provided below.
Structure: The molecule contains an Fmoc-protected nitrogen connected to a PEG chain, terminating in a carboxylic acid through a short ethylene spacer. It features aromatic carbamate functionality, ether-rich PEG segments, and a terminal alkanoic acid, yielding a flexible, water-compatible scaffold with hydrogen-bonding capacity.
Reactivity: The carboxylic acid enables amide-bond formation via standard coupling strategies using activating reagents compatible with peptide-ligand synthesis. Typical approaches include carbodiimide-based activation with additives to suppress side reactions, followed by reaction with an amine-bearing partner. The Fmoc group is removed under base conditions to expose the amine for further coupling, allowing modular PROTAC assembly through sequential protection/deprotection and conjugation steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
