Fmoc-NH-PEG19-CH2CH2COOH
Cat No.: BP-502092
4.5 
Fmoc-NH-PEG19-CH2CH2COOH is an Fmoc-protected, PEG-based bifunctional linker featuring a terminal carboxylic acid separated from the PEG chain by a two-carbon spacer. Structurally, it combines an orthogonally removable Fmoc group for solid-phase or amine-reactive coupling with a long, hydrophilic PEG segment that increases solubility and provides conformational flexibility, while the carboxylate enables formation of stable amide bonds to attach the linker to a warhead or targeting ligand. In PROTAC design, this type of linker is used to tune the spatial relationship between the ligand-binding moiety and the E3-recruiting component, helping to promote productive ternary complex formation by reducing steric constraints and improving aqueous compatibility. Its value for targeted protein degradation research lies in enabling systematic linker-length and geometry optimization, facilitating synthesis of conjugates for evaluating degradation potency, selectivity, and physicochemical performance in experimental assays.
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* For research and manufacturing use only. Not for human or clinical use.
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Fmoc-NH-PEG19-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker building block designed to provide solubility, conformational flexibility, and efficient spacing between a ligand and an E3-recruiting or target-binding moiety. The Fmoc group supports standard protected-amino chemistry for controlled coupling, while the terminal carboxylic acid enables robust conjugation strategies. These attributes make it well suited for constructing degraders where linker length and attachment chemistry strongly influence ternary complex formation and degradation efficiency. Detailed structural and reactivity considerations are provided below.
Structure: The molecule contains an Fmoc-protected amine connected to a PEG chain, terminating in a carboxylic acid through a flexible ethylene spacer. It features aromatic carbamate functionality, ether-rich PEG segments, and a terminal alkanoic acid, yielding a polar, hydrogen-bonding capable, water-compatible linker.
Reactivity: The terminal carboxylic acid can be activated for amide or ester formation using common coupling chemistries (e.g., carbodiimide-based activators with additives) under mild base conditions. The Fmoc group is typically removed under standard deprotection conditions to expose the amine for subsequent bond formation. Coupling is generally performed in polar organic solvents or mixed solvent systems compatible with PROTAC synthesis, enabling reliable linker installation without disrupting PEG integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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