Fmoc-NH-PEG30-CH2CH2COOH
Cat No.: BP-502004
4.5 
Fmoc-NH-PEG30-CH2CH2COOH is an Fmoc-protected, carboxy-terminated polyethylene glycol linker featuring a long, flexible PEG chain that provides high aqueous solubility and conformational freedom. Structurally, it combines an activated Fmoc group for solid-phase or amide-coupling synthesis, a terminal primary carboxylic acid for conjugation to amine-bearing ligands, and an ethylene glycol–like spacer that separates functional domains. In PROTAC design, such PEG linkers are commonly used to tune the spatial relationship between the target-binding ligand and the E3 ligase-recruiting moiety, helping to reduce steric clashes and improve productive ternary complex formation. The extended, hydrophilic backbone can also mitigate aggregation and enhance handling during synthesis and biological assays. As a modular building block, it supports reproducible linker engineering for targeted protein degradation studies, enabling systematic optimization of linker length and attachment chemistry while maintaining synthetic compatibility with standard coupling workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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Fmoc-NH-PEG30-CH2CH2COOH is a polyethylene glycol-based PROTAC linker building block designed to provide a hydrophilic, conformationally flexible spacer between a ligand and an electrophile-bearing handle. Its Fmoc-protected amine enables controlled stepwise synthesis, while the terminal carboxylic acid supports robust coupling strategies commonly used to assemble targeted protein degraders. The subsequent points describe its structure and the practical reactivity features relevant for PROTAC construction.
Structure: The linker comprises an Fmoc-protected amine connected to a long PEG chain, terminated by a flexible ethylene spacer and a carboxylic acid. It contains aromatic carbamate functionality, ether-rich PEG segments, and aliphatic carbon-carbon and carbon-oxygen linkages, yielding a highly solvated, flexible scaffold.
Reactivity: The Fmoc group can be removed under standard base-mediated conditions to expose the amine for subsequent coupling. The terminal carboxylic acid is suitable for activation and amide-bond formation using common coupling chemistries, enabling attachment to ligand-derived amines or other nucleophiles. Linker incorporation typically proceeds via carbodiimide or uronium-type activation in polar aprotic solvents, with bases to promote nucleophilic acyl substitution.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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