Tetrazine-Ph-PEG4-Ph-aldehyde
Cat No.: BP-501995
4.5 
Tetrazine-Ph-PEG4-Ph-aldehyde is a bifunctional, polyethylene glycol–based linker bearing a tetrazine moiety and an aldehyde handle, connected through two phenyl spacers and a short PEG chain. The PEG4 segment provides aqueous solubility and conformational flexibility, while the phenyl linkers help define spatial orientation between the reactive groups. In PROTAC and related targeted degradation workflows, the tetrazine group serves as a bioorthogonal reaction handle for fast inverse-electron-demand Diels–Alder ligation to trans-cyclooctene–functional partners, enabling modular conjugation of targeting ligands or E3 ligase binders under mild conditions. The aldehyde can be used for subsequent chemoselective coupling to amine- or hydrazide-bearing components (e.g., formation of imines or hydrazones), facilitating stepwise assembly of degraders. This linker is valuable for constructing tunable, modular degradation systems where controlled attachment chemistry and improved linker dynamics are required.
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* For research and manufacturing use only. Not for human or clinical use.
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Tetrazine-Ph-PEG4-Ph-aldehyde is a bifunctional PEG-based linker designed to support modular PROTAC construction by combining a tetrazine handle with an aldehyde for orthogonal conjugation. Its flexible poly(ethylene glycol) segment helps tune linker length, solubility, and effective spatial presentation of the warhead and E3 ligase-binding elements. The tetrazine functionality enables bioorthogonal click-type coupling strategies, while the aldehyde group provides a chemically versatile attachment point for forming stable linkages with suitable targeting ligands. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises an aromatic tetrazine moiety connected through phenyl spacers to a flexible PEG chain terminating in an aldehyde. It contains conjugated heteroaromatic rings, ether linkages within the PEG segment, and a reactive carbonyl group. Overall properties favor aqueous compatibility and conformational flexibility.
Reactivity: The aldehyde can be used for carbonyl-directed conjugation, including formation of imine or related adducts with appropriate nucleophiles under mild, controlled conditions. The tetrazine functionality is suited to inverse-electron-demand cycloaddition with strained dienes/tetrazine-reactive partners, typically performed in aqueous or mixed solvents at moderate temperatures to preserve sensitive biomolecule conjugates. Solvent choice and pH should be optimized to balance aldehyde stability and coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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