HO-PEG12-CH2COOH
Cat No.: BP-502029
4.5 
HO-PEG12-CH2COOH is a monofunctional, hydroxyl-terminated polyethylene glycol (PEG) linker bearing a terminal carboxymethyl group, providing a flexible, hydrophilic chain of moderate length suitable for PROTAC and targeted protein degradation constructs. Structurally, the PEG segment acts as a spacer that can reduce steric congestion between the two ligands of a bifunctional degrader, while the hydroxyl and carboxylic acid functionalities enable orthogonal chemical handle(s) for conjugation strategies such as esterification/amide coupling or activation of the carboxyl group for attachment to an E3-ligase ligand or a warhead. In PROTAC design, such PEG-based linkers help tune effective intramolecular proximity, improve aqueous solubility, and can influence the conformational freedom that affects ternary complex formation and subsequent ubiquitination-driven degradation. This linker is therefore valuable for researchers optimizing linker length, polarity, and coupling chemistry to systematically evaluate degradation potency and selectivity in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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HO-PEG12-CH2COOH is a PEG-based bifunctional linker designed for assembling PROTACs via reliable amide- and ester-forming chemistries. Its hydrophilic, flexible poly(ethylene glycol) segment supports productive ternary complex formation by improving solubility and reducing nonspecific interactions. The terminal carboxylic acid enables robust conjugation to targeting ligands, while the hydroxyl functionality facilitates controlled derivatization. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a poly(ethylene glycol) chain terminated by a hydroxyl group and a carboxylic acid, connected through an ether and methylene spacer. It contains ether linkages, a terminal carboxyl group, and multiple oxygen atoms that confer strong hydrogen-bonding capacity and aqueous compatibility.
Reactivity: The carboxylic acid can be activated for amide coupling to amine-bearing ligands using standard coupling reagents under mild base conditions, typically in polar aprotic solvents. The hydroxyl group can be converted to reactive intermediates (for example, via esterification) when complementary electrophiles are present. Conjugation generally follows nucleophilic acyl substitution principles, enabling modular PROTAC construction with careful control of stoichiometry and pH to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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