HO-PEG24-CH2COOH
Cat No.: BP-502079
4.5 
HO-PEG24-CH2COOH is a monofunctional polyethylene glycol (PEG) linker featuring a terminal hydroxyl group and a terminal carboxymethyl (–CH2COOH) functionality, providing a flexible, hydrophilic chain of extended length suitable for conjugation chemistry. Structurally, the PEG segment acts as a spacer that can reduce steric interference between a PROTAC’s targeting ligand and an E3 ligase–binding moiety, while the terminal carboxylic acid enables reliable coupling to amine-bearing partners via standard amide-forming reactions (e.g., EDC/NHS or related carbodiimide chemistries). In targeted protein degradation designs, such PEG linkers are commonly used to tune effective linker length, improve aqueous solubility, and modulate the relative orientation of binding domains to facilitate productive ternary complex formation. This reagent is valuable for constructing PROTACs and related bifunctional degraders, where systematic linker engineering can be critical for optimizing degradation potency and experimental robustness in biochemical and cell-based assays.
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* For research and manufacturing use only. Not for human or clinical use.
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This HO-PEG24-CH2COOH linker is a polyethylene glycol-based bifunctional tether designed to connect a ligand to an E3-recruiting or target-binding module in PROTAC architectures. Its hydrophilic PEG backbone supports solubility and conformational flexibility, which can improve productive ternary complex formation. The terminal hydroxyl and carboxymethyl functionalities enable practical conjugation strategies, and the linker is described in detail below.
Structure: The molecule comprises a PEG chain terminated by a hydroxyl group and a carboxymethyl moiety. It contains repeating ether linkages along the backbone, with an aliphatic methylene spacer adjacent to a carboxylic acid, providing a flexible, hydrophilic scaffold.
Reactivity: The carboxylic acid end can be activated for amide-bond formation with amine-bearing ligands using standard coupling chemistries under mild conditions. The hydroxyl group can be converted to reactive intermediates (for example, via ester formation) when complementary functional groups are present. Solvent systems commonly used for PROTAC conjugations include polar aprotic media, with activation reagents and base selected to preserve ligand integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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