HS-PEG7-CH2CH2COOH
Cat No.: BP-502110
4.5 
HS-PEG7-CH2CH2COOH is a thiol-terminated, carboxylic-acid functionalized polyethylene glycol linker built from a PEG7 chain with a terminal ethylene spacer and a terminal carboxyl group. Structurally, the thioether/thiol “HS–” handle enables controlled conjugation to thiol-reactive partners or to maleimide/thiol-compatible chemistries, while the terminal carboxyl group provides an anionic, hydrophilic anchor for coupling to amines or for further derivatization via standard carbodiimide-mediated reactions. In PROTAC and targeted degradation workflows, such bifunctional PEG linkers are used to tune linker length, solubility, and conformational flexibility, helping to position the E3 ligase-recruiting ligand and the target-binding ligand to form a productive ternary complex. Its PEG-based hydration layer can reduce nonspecific hydrophobic interactions and improve handling in aqueous assays, making it a useful component for systematic linker optimization and for generating well-defined conjugates for degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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This PEG-based linker, designated HS-PEG7-CH2CH2COOH, is designed to connect a thiol-bearing handle to a carboxyl-functional terminus for flexible PROTAC assembly. Its ether-rich, hydrophilic backbone supports solubility and can help maintain productive spatial presentation between targeting and E3 ligase ligands. The thiol-reactive and acid-reactive features enable modular conjugation strategies commonly used in targeted protein degradation workflows. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a polyethylene glycol segment terminated by a thiol (HS) and a terminal carboxylic acid attached through an ethylene spacer. It contains ether linkages along the PEG chain and aliphatic C–C and C–O bonds, with a polar, hydrogen-bonding-capable functional group set that favors aqueous compatibility.
Reactivity: The thiol can be used for chemoselective coupling to electrophiles (such as activated halides or maleimide-type partners) under mild, reducing-compatible conditions. The carboxylic acid is suitable for amide-bond formation via standard carboxyl activation (for example, using carbodiimide-based systems) with amines, typically in polar aprotic solvents and with base to promote nucleophilic acyl substitution. Overall, conjugation proceeds through thiol or activated-acid intermediates to yield stable linker–ligand connections.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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