HS-PEG9-CH2CH2COOH
Cat No.: BP-502087
4.5 
HS-PEG9-CH2CH2COOH is a thiol-terminated, carboxylic-acid functional polyethylene glycol linker designed for flexible conjugation in targeted protein degradation (PROTAC) workflows. Structurally, it comprises a PEG chain that provides hydrophilicity and conformational mobility, terminating on one end with a reactive thiol handle and on the other end with a terminal carboxyl group suitable for amide coupling or other carboxyl-directed chemistries. In PROTAC architectures, such linkers are used to spatially separate a ligand that recruits an E3 ligase from the substrate-binding moiety, thereby tuning effective ternary complex formation and improving productive proximity for ubiquitination-driven degradation. The PEG segment also helps reduce nonspecific hydrophobic interactions and can enhance aqueous solubility of bulky conjugates. As a modular building block, HS-PEG9-CH2CH2COOH enables systematic linker-length and attachment-site optimization, supporting experimental studies aimed at maximizing degradation potency and selectivity while maintaining synthetic accessibility.
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* For research and manufacturing use only. Not for human or clinical use.
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HS-PEG9-CH2CH2COOH is a polyethylene glycol-based PROTAC linker designed to connect a terminal thiol handle to a carboxylic acid functionality. Its flexible, hydrophilic PEG segment supports productive ternary complex formation by improving solubility and conformational adaptability, while the dual reactive ends enable modular conjugation to diverse ligands. This molecule will be described in detail below, including its structural features and practical considerations for PROTAC assembly.
Structure: The linker contains a PEG backbone providing ether-rich, flexible segments, terminated by a thiol (HS) and a carboxylic acid. It features typical C–O and C–C connectivity of PEG chains, with a terminal alkyl spacer bearing a carboxylate-forming functional group, enabling hydrophilic behavior and stable amide or thioether formation.
Reactivity: The carboxylic acid end is suitable for activation toward amide bond formation (e.g., via common coupling reagents) with amine-bearing ligands under standard peptide-coupling conditions. The terminal thiol can be used for thiol–maleimide or thiol–activated electrophile conjugations, or for forming thioether linkages after appropriate activation. Mild aqueous/organic solvent mixtures and controlled pH are typically used to preserve thiol integrity and drive coupling efficiently.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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