N3-PEG16-Hydrazide
Cat No.: BP-502098
4.5 
N3-PEG16-Hydrazide is a polyethylene glycol (PEG) linker bearing a terminal hydrazide functionality and an N3-reactive handle suitable for conjugation chemistry. Structurally, it consists of a PEG chain of approximately sixteen ethylene glycol units that provides water solubility and conformational flexibility, while the hydrazide group enables formation of stable hydrazone linkages with aldehyde-containing partners or coupling to carbonyl-activated biomolecules under appropriate conditions. In PROTAC design, such linkers are used to spatially separate the targeting ligand and the recruited E3 ligase moiety, helping to reduce steric interference and to tune the effective geometry for ternary complex formation. The hydrazide end can serve as a controllable conjugation site for assembling multi-component degraders, including constructs where reversible or carbonyl-mediated attachment is advantageous during synthesis. This product is therefore valuable for researchers optimizing linker length and attachment strategy to improve targeted protein degradation performance and experimental reproducibility.
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* For research and manufacturing use only. Not for human or clinical use.
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N3-PEG16-Hydrazide is a polyethylene glycol (PEG)-based linker bearing a hydrazide functional group, designed to support the modular assembly of PROTACs. Its PEG scaffold enhances solubility and provides a flexible spacer that can improve productive ternary complex formation by reducing steric constraints between the target-binding ligand and the E3 ligase-recruiting moiety. The hydrazide handle enables reliable conjugation strategies commonly used in targeted protein degradation workflows; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG chain terminated with a hydrazide, featuring ether linkages along the polymer backbone and an acyl-hydrazine motif at the reactive terminus. This combination yields a flexible, hydrophilic spacer with hydrogen-bonding capacity, supporting favorable aqueous behavior and conformational adaptability in PROTAC constructs.
Reactivity: The hydrazide group is typically engaged through acyl-transfer or condensation-based conjugation routes, including formation of hydrazone linkages with aldehyde-functional partners under mildly acidic conditions. Alternatively, hydrazide-to-activated-carboxyl or acyl-derivative coupling approaches can be used depending on the complementary warhead chemistry. Reactions are commonly performed in compatible organic/aqueous mixtures, with coupling reagents or acid catalysts selected to preserve PEG integrity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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