Hydroxy-PEG12-acid
Cat No.: BP-502003
4.5 
Hydroxy-PEG12-acid is a polyethylene glycol–based linker bearing a terminal hydroxyl group and a terminal carboxylic acid, providing a flexible, hydrophilic tether of extended length suitable for PROTAC construction. Structurally, the repeating ether units confer conformational mobility and aqueous solubility, while the carboxylate handle enables straightforward conjugation to electrophilic partners (e.g., via amide formation) or incorporation into bifunctional degraders through standard linker chemistry. In targeted protein degradation workflows, such PEG linkers help position the ligand-recruiting warheads at an appropriate spatial distance, promoting productive ternary complex formation with the E3 ligase and the target protein while reducing steric clashes and nonspecific hydrophobic interactions. Its PEG architecture is also commonly used to improve physicochemical properties and to tune linker length and flexibility during iterative PROTAC optimization.
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* For research and manufacturing use only. Not for human or clinical use.
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Hydroxy-PEG12-acid is a polyethylene glycol-based linker designed to connect ligands in targeted protein degradation (PROTAC) constructs. Its hydrophilic PEG segment supports solubility and conformational flexibility, while the terminal carboxylic acid enables reliable conjugation to targeting or E3-recruiting moieties. These features help researchers build stable, well-behaved PROTAC architectures for systematic structure–activity studies; detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a PEG chain terminated by a carboxylic acid and a hydroxyl group, providing an ether-rich, flexible backbone. It contains multiple ether linkages and a terminal acid functionality capable of forming hydrogen bonds and salts. Overall, it is highly polar and water-compatible, supporting favorable handling and dispersion in common organic solvents.
Reactivity: The terminal carboxylic acid is suited for amide or ester bond formation with complementary amine- or alcohol-bearing ligands under standard peptide-coupling or esterification conditions. Typical approaches use coupling reagents and base in polar aprotic solvents to activate the acid toward nucleophilic substitution, enabling formation of stable PROTAC linkages. Reaction success depends on maintaining controlled pH, minimizing hydrolysis, and ensuring orthogonal functional group compatibility during sequential assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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