Hydroxy-PEG3-acid
CAS No.: 518044-49-0
Cat No.: BP-501031
Purity: >95%
4.5 
Hydroxy-PEG3-acid is a PEG-based linker featuring a terminal carboxylic acid and a hydroxyl group, providing a short, hydrophilic spacer of approximately three ethylene glycol units. In PROTAC architectures, such PEG linkers are widely used to tune the relative positioning and effective reach between the ligand that recruits an E3 ubiquitin ligase and the target-binding moiety, while reducing steric clashes and improving aqueous solubility. The carboxylate functionality enables straightforward conjugation to amine- or hydrazide-bearing partners via standard amide or related coupling chemistries, allowing construction of stable, well-defined degraders. Its flexible, water-compatible chain can help maintain productive ternary complex formation by allowing conformational adaptation during binding. As a modular building block, Hydroxy-PEG3-acid is valuable for systematic linker optimization in targeted protein degradation studies, supporting comparisons of geometry, solubility, and degradation potency across closely related PROTAC variants.
Structure of 518044-49-0
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Hydroxy-PEG3-acid is a polyethylene glycol-based PROTAC linker designed to provide a hydrophilic, flexible spacer between binding elements and to support efficient formation of ternary complexes. Its terminal acid functionality enables robust conjugation strategies commonly used in targeted protein degradation workflows. The linker’s ether-rich backbone helps tune solubility and conformational freedom, which can improve practical construct assembly and downstream biochemical evaluation. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a short PEG segment with repeating ether linkages, terminating in a carboxylic acid and a hydroxyl group. It features polar oxygen atoms capable of hydrogen bonding, offering high aqueous compatibility and conformational flexibility typical of PEG-based spacers.
Reactivity: The terminal carboxylic acid is suitable for standard amide or ester coupling reactions to connect PROTAC binding motifs under mild, activation-based conditions. Common approaches use carboxyl-activating reagents with amine partners, optionally in polar aprotic solvents and with base to promote nucleophilic acyl substitution. Reaction design should account for PEG solvation and minimize hydrolysis by controlling water content and reaction time.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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