Hydroxy-PEG6-acid
CAS No.: 1347750-85-9
Cat No.: BP-501692
Purity: >98%
4.5 
Hydroxy-PEG6-acid is a polyethylene glycol–based linker bearing a terminal hydroxyl group and a carboxylic acid handle, providing a flexible, hydrophilic spacer commonly used to connect PROTAC components. The PEG chain length and ether-rich backbone promote solubility and reduce steric congestion, while the acid functionality enables straightforward conjugation strategies such as amide bond formation with activated carboxyl derivatives or coupling to amine-bearing ligands. In PROTAC design, such linkers help tune the effective distance and relative orientation between the target-binding moiety and the E3 ligase recruiter, thereby improving productive ternary complex formation and degradation efficiency. Hydroxy-PEG6-acid is therefore a valuable building block for researchers optimizing linker length, polarity, and attachment chemistry in targeted protein degradation workflows, including systematic structure–activity relationship studies and the preparation of modular PROTAC analog libraries.
Structure of 1347750-85-9
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Hydroxy-PEG6-acid is a polyethylene glycol-based linker designed for constructing PROTACs and other bifunctional degraders that require controlled spacing and improved aqueous compatibility. Its polyether chain provides conformational flexibility and can help reduce steric interference between the target-binding ligand and the E3-recruiting module. The hydroxy and carboxy functionalities enable reliable conjugation strategies, supporting systematic linker-length tuning and facilitating experimental optimization. Detailed structural and reactivity guidance is provided below.
Structure: The linker is built from a PEG polyether backbone featuring repeating ether oxygen atoms, with a terminal hydroxy group and a terminal carboxylic acid. It contains stable C–O and C–C bonds, with a polar, hydrogen-bonding-rich architecture that supports water solubility and flexible conformations.
Reactivity: The carboxylic acid can be activated for amide-bond formation using standard coupling chemistries (for example, carbodiimide-based activation with an auxiliary coupling reagent). The hydroxy group can be used for esterification or conversion to activated carbonate/halide intermediates depending on the partner functional group. Reactions are typically performed under anhydrous, inert or moisture-controlled conditions to minimize hydrolysis, with polar aprotic solvents commonly used to support solubility and coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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