Hydroxy-PEG7-Boc
Cat No.: BP-502000
4.5 
Hydroxy-PEG7-Boc is a polyethylene glycol (PEG) linker bearing a terminal hydroxy group and a tert-butyl ester-protected carboxyl group, providing a flexible, hydrophilic chain of intermediate length suitable for PROTAC synthesis. Structurally, the PEG segment acts as a solubilizing spacer that reduces steric interference between the ligand-binding moieties, while the tert-butyl ester enables controlled functionalization for subsequent coupling steps and can be removed under acidic conditions to expose the carboxylic acid. In targeted protein degradation constructs, such linkers help position an E3-ligase ligand and a target-binding ligand at an appropriate distance and orientation to promote formation of a productive ternary complex. This product is therefore valuable for researchers optimizing linker length, polarity, and attachment chemistry in PROTACs, where improved aqueous compatibility and tunable spatial reach often translate into more consistent degradation performance across linker variants.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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Hydroxy-PEG7-Boc is a polyethylene glycol-based PROTAC linker featuring a terminal hydroxyl group and a Boc-protected functionality that enables controlled, stepwise assembly of targeted protein degraders. Its ether-rich, flexible scaffold supports productive ternary complex formation by providing distance and conformational adaptability between the ligand warhead and the E3-recruiting module. The subsequent points describe its structural characteristics and practical considerations for PROTAC construction in detail below.
Structure: The linker consists of an ether-containing PEG chain terminated by a hydroxyl group and bearing a Boc-protected group. It contains multiple C–O–C ether linkages that confer flexibility, polarity, and improved solubility, while the Boc moiety provides a stable, masked reactive handle under mild conditions.
Reactivity: For PROTAC synthesis, the Boc group is typically removed under acid-mediated conditions to reveal a reactive amine for subsequent coupling. The terminal hydroxyl can be used for derivatization through standard hydroxyl-activation or ester formation strategies. Coupling steps commonly employ amide-forming chemistries using appropriate coupling reagents and dry, polar organic solvents, following established PROTAC linker assembly workflows.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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