Iodo-PEG4-N3
CAS No.: 936917-36-1
Cat No.: BP-501229
4.5 
Iodo-PEG4-N3 is a heterobifunctional polyethylene glycol linker featuring an ω-iodo substituent and a terminal azide (N3) group, providing a flexible, water-soluble chain well suited for PROTAC assembly. The PEG backbone (four ethylene glycol units) confers conformational mobility and reduces steric interference between the two binding modules, while the iodide enables efficient site-specific functionalization via nucleophilic substitution or related coupling strategies to install the linker onto a targeting ligand or handle-bearing intermediate. The terminal azide then serves as a robust orthogonal “click” partner, allowing conjugation to complementary alkyne-functionalized components (e.g., warheads or E3 ligase ligands) through copper-catalyzed or strain-promoted azide–alkyne cycloaddition. In targeted protein degradation research, this linker architecture supports modular PROTAC design by improving effective molarity and maintaining productive ternary complex formation, facilitating systematic optimization of linker length and attachment geometry across degradation constructs.
Structure of 936917-36-1
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Iodo-PEG4-N3 is a PEG-based bifunctional linker designed for modular PROTAC assembly, combining an electrophilic iodide handle with an azide functional group for orthogonal conjugation. Its polyethylene glycol segment supports solubility and flexible spatial presentation of ligands, which can improve productive ternary complex formation. The molecule is well suited for stepwise synthesis strategies in targeted protein degradation workflows; detailed structural and reactivity considerations are provided below.
Structure: The linker contains a PEG chain that provides hydrophilic, conformational flexibility, terminated by a primary alkyl iodide and an azide group. It features carbon–oxygen ether linkages within the PEG backbone and a carbon–iodine bond at the iodinated terminus, alongside a terminal azide suitable for click-type transformations.
Reactivity: The primary alkyl iodide serves as an electrophilic site for SN2 substitution with suitable nucleophiles, enabling attachment of ligand fragments. The azide is compatible with copper-catalyzed azide–alkyne cycloaddition or related azide click chemistries to form stable triazole linkages. Typical approaches use appropriate bases and polar aprotic or mixed solvents to support SN2 substitution while maintaining solubility and reaction efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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