Lipoamido-PEG2-alcohol
CAS No.: 1674386-82-3
Cat No.: BP-501353
Purity: ≥95%
4.5 
Lipoamido-PEG2-alcohol is a short, flexible polyethylene glycol (PEG) linker bearing a terminal primary alcohol and an amide-linked lipophilic “lipoamido” handle. Structurally, it provides a two–ethylene glycol unit spacer that can be used to tune solubility and reduce steric interference between a PROTAC’s binding moiety and its E3 ligase–recruiting partner. In PROTAC design, PEG-based linkers are widely employed to improve aqueous compatibility and to modulate the effective orientation and distance required for productive ternary complex formation. The terminal alcohol enables straightforward functionalization to generate conjugation-ready intermediates (e.g., via esterification or ether/urethane formation) while the amide/lipoamido element supports stable attachment to hydrophobic pharmacophores or other linker segments. This product is valuable for researchers optimizing linker length and polarity in targeted protein degradation constructs, where small changes in spacing and flexibility can significantly impact degradation potency and selectivity.
Structure of 1674386-82-3
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Lipoamido-PEG2-alcohol is a PEG-based linker building block designed to support targeted protein degradation workflows in PROTAC construction. Its ether-rich, flexible scaffold helps tune linker length and conformational freedom between the two binding elements, while the terminal alcohol provides a practical functional handle for conjugation. This product is well suited for assembling degraders that require controlled geometry and reliable coupling chemistry; detailed structural and reactivity considerations are provided below.
Structure: The molecule contains a short poly(ethylene glycol) segment with ether linkages that confer flexibility and hydrophilicity. A lipoamide-derived amide linkage connects the PEG portion, and a terminal primary alcohol enables further derivatization. Overall, it presents multiple hydrogen-bonding sites and a polar, linker-like character.
Reactivity: The terminal alcohol can be converted into activated ester or leaving-group derivatives (commonly via standard alcohol-to-ester/ether transformations) to enable coupling with complementary PROTAC fragments bearing appropriate nucleophiles. Amide formation strategies typically rely on carbodiimide-mediated coupling or acyl-transfer approaches under mild conditions. Solvents such as polar aprotic media or alcohol-compatible systems are commonly used to maintain solubility and reaction efficiency, while catalysts are chosen according to the activation method.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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