m-PEG12-Hydrazide
Cat No.: BP-502109
4.5 
m-PEG12-Hydrazide is a monodisperse methoxy-terminated polyethylene glycol linker bearing a hydrazide functional group, providing a flexible, water-compatible chain of intermediate length suitable for conjugation chemistry. Structurally, the PEG segment acts as a hydrophilic spacer that can reduce steric interference and improve solubility of PROTAC constructs, while the hydrazide enables formation of hydrazone or hydrazide-based coupling handles with complementary carbonyl-containing partners. In targeted protein degradation workflows, such linkers are used to connect a ligand-recruiting module to an E3 ligase–binding moiety through a chemically addressable attachment point, thereby tuning the effective distance, orientation, and local microenvironment required for productive ternary complex formation. The PEG hydrazide design is valuable for researchers seeking reproducible linker architectures that facilitate synthesis and downstream characterization of PROTACs, including optimization of physicochemical properties and degradation potency in cellular assays.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG12-Hydrazide is a polyethylene glycol (PEG)-based linker designed to support PROTAC assembly by providing a hydrazide handle for robust conjugation chemistry. Its PEG character improves solubility and can help modulate linker flexibility, which is often beneficial for achieving productive ternary complex formation. The hydrazide functionality enables formation of stable hydrazone or related conjugates with appropriate partner groups, making it useful for constructing targeted protein degraders. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG chain terminated with a meta-substituted aromatic hydrazide functionality. It contains ether linkages along the PEG backbone, an aromatic ring, and a hydrazide moiety capable of hydrogen bonding. Overall polarity and conformational flexibility are characteristic of PEG-based spacers.
Reactivity: The hydrazide group can participate in hydrazone-forming condensation reactions with aldehyde- or ketone-functional partners under controlled acid-catalyzed conditions, typically in polar organic or mixed aqueous media. Conjugation proceeds via nucleophilic addition of the hydrazide followed by dehydration to yield the hydrazone linkage. Mild acids or buffering systems are commonly used to tune rate and selectivity, while protecting groups may be employed to preserve other reactive functionalities during PROTAC synthesis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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