m-PEG13-Hydrazide
Cat No.: BP-502077
4.5 
m-PEG13-Hydrazide is a methoxy-terminated polyethylene glycol linker bearing a terminal hydrazide functionality, providing a flexible, water-soluble chain that can span distances between a targeting ligand and an E3-recruiting or warhead module. The PEG segment helps reduce steric constraints and can improve aqueous compatibility of conjugates, while the hydrazide group serves as a reactive handle for forming hydrazone linkages with aldehyde-bearing partners or for hydrazide-to-acyl/activated-ester coupling strategies used to attach biomolecular targeting moieties. In PROTAC and targeted protein degradation workflows, such linkers are commonly used to tune linker length, conformational freedom, and effective intramolecular proximity, thereby influencing ternary complex formation and degradation potency. This product is valuable for researchers seeking modular assembly of degradation constructs, enabling systematic variation of spatial arrangement and stability of the conjugation chemistry during optimization experiments.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
m-PEG13-Hydrazide is a polyethylene glycol (PEG)-based linker designed for assembling PROTACs and related targeted degradation constructs. Its hydrazide functionality enables robust conjugation to complementary electrophiles, while the PEG spacer supports solubility and can help tune the effective distance and flexibility between the targeting ligand and the E3-recruiting element. The combination of a PEG backbone with a reactive hydrazide makes this linker well suited for modular synthesis and subsequent structure–activity optimization; the detailed structural and reactivity considerations are provided below.
Structure: The linker contains a PEG chain terminated with a hydrazide group, providing a flexible, ether-rich scaffold. It features multiple ether linkages along the polymer segment and a terminal carbonyl within the hydrazide, enabling hydrogen bonding and polar surface interactions that support aqueous compatibility.
Reactivity: The hydrazide moiety is commonly used for acyl hydrazone formation with aldehydes under mild conditions, or for coupling strategies that activate the hydrazide toward amide bond formation when appropriate electrophiles are used. Typical PROTAC linker assembly is performed in polar organic solvents or buffered mixtures, with reaction control guided by pH and water content to balance hydrazone stability and conjugation efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
