m-PEG17-Hydrazide
Cat No.: BP-502021
4.5 
m-PEG17-Hydrazide is a methoxy-capped polyethylene glycol (PEG) linker bearing a hydrazide functional group, providing a flexible, water-soluble spacer of intermediate length suitable for conjugation chemistry. In PROTAC and related targeted degradation constructs, PEG linkers are commonly used to tune the spatial relationship between the ligand warhead(s) and the E3-recruiting module, reducing steric clashes and helping maintain productive ternary complex formation. The hydrazide group enables formation of stable hydrazone linkages with appropriately functionalized carbonyl-containing partners or can serve as a reactive handle for coupling strategies that introduce degraders, affinity tags, or other modular elements under mild conditions. This product is valuable for researchers seeking to systematically vary linker length and attachment chemistry to optimize degradation potency, selectivity, and physicochemical properties such as solubility and reduced aggregation in aqueous assay media.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG17-Hydrazide is a polyethylene glycol (PEG)-based hydrazide linker designed to support the modular synthesis of PROTACs by providing a hydrophilic, flexible spacer between targeting and recruiting elements. Its hydrazide functionality enables robust conjugation strategies commonly used to assemble bifunctional degraders, improving solubility and facilitating controlled spatial presentation of ligands. The following points describe the linker’s structure and the practical reactivity considerations for PROTAC construction in detail below.
Structure: The linker consists of a PEG chain terminated with a hydrazide group, featuring ether linkages along the polymer backbone and a terminal carbonyl within the hydrazide. This combination yields a flexible, water-compatible scaffold with polar hydrogen-bonding capacity that can modulate linker length and conformational freedom in PROTAC architectures.
Reactivity: The hydrazide can participate in acyl-hydrazone formation with carbonyl-containing partners under mild condensation conditions, and it can also be used in coupling workflows that rely on nucleophilic acyl substitution or subsequent derivatization of the hydrazide functionality. Typical PROTAC assembly uses compatible polar solvents and controlled pH to promote selective bond formation while minimizing PEG chain degradation and side reactions; catalysts are generally chosen to match the specific conjugation chemistry employed.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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