m-PEG24-Br
Cat No.: BP-502037
4.5 
m-PEG24-Br is a methoxy-terminated, bromide-activated polyethylene glycol linker designed for PROTAC and targeted protein degradation workflows requiring a flexible, hydrophilic spacer. Structurally, it consists of a linear PEG chain of extended length capped with a terminal methoxy group and a reactive bromine at the opposite end, enabling efficient functionalization via nucleophilic substitution to introduce an attachment handle for conjugation to either the ligand (warhead) or the E3-recruiting moiety. In PROTAC architectures, PEG linkers help tune the effective distance and conformational freedom between binding elements, often improving productive ternary complex formation while reducing nonspecific hydrophobic interactions. The bromide provides a practical synthetic entry point for preparing site-specific conjugates under standard organic conditions, supporting rapid generation of linker variants for structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG24-Br is a bromo-terminated polyethylene glycol linker designed for modular assembly of PROTACs, enabling efficient conjugation of targeting ligands to E3-recruiting moieties through robust ether-based PEG scaffolding. Its flexible, hydrophilic chain supports favorable solubility and reduced nonspecific interactions, while the terminal bromide provides a practical handle for subsequent functionalization. The detailed structural and reactivity considerations for constructing PROTAC intermediates are provided below.
Structure: The linker consists of a repeating PEG ether backbone terminating in a primary bromide. It contains multiple ether linkages that confer conformational flexibility and strong hydrogen-bonding capacity, yielding a hydrophilic, low-interfacial-tension material. The terminal C–Br bond serves as a reactive electrophilic site for substitution.
Reactivity: The bromide terminus is suitable for nucleophilic substitution reactions to install PROTAC coupling groups, typically under conditions that promote SN2-type displacement. Common approaches use nucleophiles such as amines, thiols, or carboxylate-derived species in polar aprotic or mixed solvents, often with base to enhance nucleophile reactivity. Reaction design should account for PEG solubility and minimize competing hydrolysis of the bromide.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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