m-PEG25-Propargyl
Cat No.: BP-502095
4.5 
m-PEG25-Propargyl is a methoxy-capped polyethylene glycol linker bearing a terminal propargyl (alkyne) group, designed to provide a flexible, hydrophilic spacer between PROTAC components. The PEG chain length and ether-rich backbone enhance solubility and reduce non-specific hydrophobic interactions, while the propargyl functionality enables bioorthogonal conjugation via copper-catalyzed azide–alkyne cycloaddition or related click chemistry to attach the linker to azide-bearing targeting ligands or E3-recruiting moieties. In PROTAC architectures, this type of linker helps tune the effective distance and relative orientation of the two binding domains, which can be critical for efficient ternary complex formation and subsequent ubiquitination-driven degradation. As a modular PEG–alkyne building block, it is valuable for constructing and optimizing targeted protein degradation probes, facilitating systematic structure–activity studies and improving experimental handling of conjugates in aqueous media.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG25-Propargyl is a PEG-based PROTAC linker featuring a terminal propargyl (alkyne) handle that enables modular conjugation of ligands for targeted protein degradation. Its flexible, hydrophilic PEG scaffold can improve solubility and reduce nonspecific interactions, while the reactive alkyne supports efficient “click” coupling to azide-bearing partners. This combination makes the linker well-suited for constructing degraders with controlled connectivity; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a meta-substituted polyethylene glycol chain bearing a terminal propargyl group. It contains ether linkages within the PEG backbone and a carbon–carbon triple bond at the propargyl terminus, providing a flexible, water-compatible scaffold suitable for bioconjugation chemistry.
Reactivity: The propargyl functionality is designed for copper-catalyzed azide–alkyne cycloaddition with azide-functionalized ligands or intermediates. Typical approaches employ a Cu(I) source, a stabilizing ligand, and an appropriate aqueous or mixed solvent system to promote regioselective triazole formation. Reaction efficiency depends on substrate solubility and oxygen sensitivity of Cu(I); standard click protocols and careful quenching are used to obtain clean conjugates for PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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