m-PEG3-aldehyde
CAS No.: 356066-46-1
Cat No.: BP-501439
4.5 
m-PEG3-aldehyde is a short, methoxy-terminated polyethylene glycol aldehyde building block featuring a three–ethylene glycol unit spacer terminated with an aldehyde functional group. The PEG chain provides aqueous solubility and conformational flexibility, while the aldehyde enables chemoselective conjugation through aldehyde–amine coupling (e.g., formation of reversible imines or stable reductive amination after reduction). In PROTAC design, such PEG aldehyde linkers are commonly used to connect targeting ligands or E3-recruiting modules to other components while minimizing steric interference and preserving binding interactions. The flexible, hydrophilic spacer can improve effective molarity at the ternary complex interface and reduce nonspecific aggregation, thereby supporting more reliable degradation assay readouts. As a modular intermediate, m-PEG3-aldehyde is valuable for preparing linker-defined PROTACs and related targeted degradation constructs where controlled attachment chemistry and tunable linker length are critical.
Structure of 356066-46-1
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m-PEG3-aldehyde is a polyethylene glycol (PEG)-functional aldehyde designed to serve as a versatile PROTAC linker component, enabling efficient conjugation to amine- or hydrazide-bearing targeting ligands or intermediate scaffolds. Its PEG character supports improved solubility and conformational flexibility, which can help maintain productive ternary complex formation in targeted protein degradation workflows. The detailed Structure and Reactivity parameters are provided below.
Structure: The linker comprises a short PEG chain terminated by a terminal aldehyde, featuring ether linkages along the polymer backbone and a reactive carbonyl group at the terminus. The aldehyde enables formation of reversible and irreversible conjugates, while the PEG segment imparts hydrophilicity and chain mobility.
Reactivity: The aldehyde group can undergo condensation with primary amines to form imines, or with hydrazides to form hydrazones, typically under mild, aqueous or mixed-solvent conditions. For stable linker installation, reductive amination is commonly used, relying on an aldehyde–amine condensation followed by reduction. Catalysts are often not required, but pH control and compatible reducing agents are critical to minimize side reactions and preserve ligand integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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