m-PEG3-S-PEG1-C2-Boc
Cat No.: BP-501958
4.5 
m-PEG3-S-PEG1-C2-Boc is a bifunctional PEG-based linker designed for constructing PROTACs and other targeted protein degradation conjugates. Structurally, it contains short polyethylene glycol segments that provide aqueous solubility and conformational flexibility, connected through a thioether linkage (S) that can serve as a stable spacer between two functional termini. The C2 tert-butyl ester end protects a carboxyl handle for subsequent coupling chemistries after deprotection, enabling attachment to a ligand (e.g., E3 ligase binder or target-binding moiety) while minimizing premature side reactions during synthesis. In PROTAC design, such linkers help tune the effective distance and relative orientation between binding domains, which is critical for productive ternary complex formation and downstream ubiquitination. This product is valuable for researchers seeking modular, PEG-mediated linker architectures to optimize degradation potency and experimental tractability through controlled conjugation and purification workflows.
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* For research and manufacturing use only. Not for human or clinical use.
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This m-PEG3-S-PEG1-C2-Boc linker is designed to serve as a modular connection element in PROTAC synthesis, enabling controlled spatial presentation and tunable physicochemical properties through polyethylene glycol segments. Its thioether-containing linkage and protected functional group facilitate stepwise assembly of conjugates while supporting solubility and handling in common organic reaction media. The details below describe the linker’s structure and practical reactivity considerations for constructing targeted protein degraders.
Structure: The linker incorporates PEG-based ether chains that impart hydrophilicity and conformational flexibility, connected through a sulfur-containing thioether motif. A protected carboxylate/amine functionality is present as a Boc group, providing stability under neutral conditions while remaining available for later deprotection.
Reactivity: For PROTAC construction, the Boc-protected handle is typically carried through coupling steps under conditions compatible with Boc stability, then revealed via acid-mediated deprotection to enable amide or carbamate-forming reactions. The thioether linkage supports chemoselective conjugation strategies that avoid oxidation-sensitive steps. Common approaches use activated carboxylic acid derivatives or coupling reagents in polar organic solvents, with base and inert atmosphere to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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