m-PEG36-alcohol
Cat No.: BP-501942
4.5 
m-PEG36-alcohol is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal alcohol, providing a long, hydrophilic, flexible chain for constructing PROTACs and related targeted protein degraders. Structurally, the PEG segment offers a defined spacer length and conformational freedom, while the alcohol functionality enables straightforward derivatization (e.g., conversion to activated esters, carbamates, or ether/ester linkages) to connect the linker to a ligand-bearing warhead or to a recruitment module. In PROTAC design, such PEG linkers can reduce steric clashes between the two binding domains, improve effective molarity at the ternary complex interface, and enhance aqueous solubility and handling of conjugates, which are common constraints when assembling large, multi-domain degraders. This product is therefore valuable for systematic linker optimization, allowing researchers to tune spatial separation and physicochemical properties to support robust formation of the target–degrader–E3 ligase ternary complex.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG36-alcohol is a polyethylene glycol (PEG)-based linker designed to provide a flexible, hydrophilic spacer for assembling PROTACs and related targeted protein degradation constructs. Its ether-rich backbone supports solubility and can help tune the effective distance and conformational freedom between the ligand moieties, which is often critical for efficient ternary complex formation. The flexible linker architecture and terminal alcohol functionality make it broadly compatible with common PROTAC conjugation strategies; detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a PEG chain featuring repeating ether units and a terminal hydroxyl group, enabling hydrogen bonding and strong water compatibility. Its backbone is composed of C–O ether linkages with a flexible, conformationally mobile polyether framework, typically yielding an amorphous, hydrophilic material suitable for bioconjugation workflows.
Reactivity: The terminal alcohol enables standard PROTAC linker functionalization via hydroxyl-selective derivatization, including esterification or ether formation using activated carboxylic acids or electrophilic coupling partners. Typical approaches rely on mild base-mediated coupling, with polar aprotic solvents to maintain solubility and promote nucleophilic substitution. Reaction design generally follows established bioconjugation principles to preserve ligand integrity and minimize side reactions during linker installation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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