m-PEG36-azide
Cat No.: BP-501836
4.5 
m-PEG36-azide is a methoxy-terminated polyethylene glycol linker bearing a terminal azide group, providing a flexible, hydrophilic chain for controlled spacing and facile chemical conjugation. Structurally, the PEG segment acts as a solubilizing spacer that can reduce steric interference between a target-binding ligand and an E3 ligase recruiter, while the azide enables modular attachment via azide–alkyne cycloaddition (CuAAC or strain-promoted variants) to install PROTAC “warheads” or to functionalize building blocks under mild conditions. In PROTAC design, this linker supports efficient formation of ternary complexes by tuning effective linker length and conformational freedom, and it can be used to generate well-defined conjugates for systematic structure–activity studies. Its value for targeted protein degradation research lies in providing reproducible, water-compatible linker chemistry that facilitates rapid synthesis of PROTAC analog series and subsequent biochemical evaluation of degradation potency and selectivity.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG36-azide is a polyethylene glycol (PEG) linker bearing a terminal azide functionality, designed for modular construction of PROTACs and related targeted protein degradation reagents. Its PEG-rich scaffold supports solubility and flexible spacing between ligand units, while the azide enables efficient, bioorthogonal conjugation. The subsequent points describe the linker’s structural features and practical reactivity considerations for assembling PROTAC architectures.
Structure: The molecule consists of a PEG chain terminated with an azide group. It features repeating ether linkages that confer conformational flexibility and hydrophilicity, along with a terminal N3 functional group suitable for click-type coupling. The overall structure is typically non-crystalline and water-compatible.
Reactivity: The azide reacts under copper(I)-catalyzed azide–alkyne cycloaddition with terminal alkynes to form stable triazole linkages, a widely used strategy for PROTAC and linker conjugation. Alternatively, strain-promoted azide–alkyne cycloaddition can be used to avoid copper. Common conditions employ polar solvents and appropriate bases or reducing systems to generate active copper(I) species when applicable, while maintaining compatibility with sensitive ligands.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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