m-PEG5-phosphonic acid ethyl ester
CAS No.: 1807512-42-0
Cat No.: BP-501385
Purity: ≥95%
4.5 
m-PEG5-phosphonic acid ethyl ester is a heterobifunctional PEG-based linker featuring a methoxy-terminated PEG5 chain and a diethyl phosphonate group, providing a chemically versatile handle for PROTAC assembly. The PEG segment contributes water solubility and conformational flexibility, helping to reduce steric interference between the target-binding ligand and the E3 ligase-recruiting moiety while promoting productive ternary complex formation. The diethyl phosphonate mainly serves as a protected phosphonate motif and can be de-esterified to a more polar phosphonic acid; it is not a standard direct covalent-coupling handle. In targeted protein degradation research, this linker is valuable for tuning linker length, hydrophilicity, and spatial orientation, which are key determinants of cellular uptake, stability, and degradation potency.
Structure of 1807512-42-0
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m-PEG5-phosphonic acid ethyl ester is a PEG-based linker designed to support targeted protein degradation (PROTAC) architectures by providing aqueous compatibility, conformational flexibility, and a chemically addressable phosphonate handle. Its ether-rich chain can help tune linker length and solvation, while the phosphonate functionality enables robust coupling strategies to assemble bifunctional degraders. The detailed Structure and Reactivity parameters are provided below.
Structure: This linker contains a methoxy-terminated polyethylene glycol (PEG) ether backbone and a phosphonate group protected as a diethyl ester. The structure features ether linkages and a fully esterified phosphonate P–O framework, yielding a polar scaffold that can provide ionizable phosphonic-acid functionality after dealkylation.
Reactivity: The diethyl phosphonate ester can be converted to the corresponding phosphonic acid under standard phosphonate-ester dealkylation conditions used in linker chemistry. After appropriate dealkylation, the resulting phosphonic acid can be further derivatized using conditions selected for phosphonate chemistry and partner compatibility. Mild aqueous/organic solvent mixtures are typically employed to maintain PEG integrity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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