m-PEG8-Boc
Cat No.: BP-501763
4.5 
m-PEG8-Boc is a methoxy-terminated polyethylene glycol (PEG) linker bearing a Boc-protected functional group, designed to provide a flexible, hydrophilic spacer for bioconjugation and PROTAC assembly. Structurally, it comprises an m-PEG chain of intermediate length with a terminal Boc moiety that can be used as a protected handle for subsequent coupling strategies, while the PEG segment helps tune solubility, reduce nonspecific hydrophobic interactions, and provide conformational freedom between the ligand-binding warhead and the recruited E3 ligase component. In targeted protein degradation workflows, such PEG-based linkers are commonly employed to modulate effective distance and relative orientation, thereby improving productive ternary complex formation and degradation potency. This product is valuable for researchers optimizing linker length and physicochemical properties during PROTAC synthesis, enabling systematic evaluation of how spacer flexibility and polarity influence cellular activity and stability.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG8-Boc is a polyethylene glycol-based linker with a tert-butyl ester-protected carboxyl group, designed to support the synthesis of PROTAC constructs by providing a flexible, hydrophilic spacer. Its PEG character can improve aqueous compatibility and help tune the spatial relationship between the target-binding ligand and the E3-recruiting moiety. The subsequent points describe the structure and practical considerations for PROTAC assembly using this linker.
Structure: The molecule combines a polyethylene glycol chain with a tert-butyl ester-protected carboxyl group, featuring ether linkages along the PEG backbone and an ester functionality at the protected terminus. This architecture yields a flexible, polar, and conformationally adaptable spacer suitable for bioconjugation workflows.
Reactivity: The tert-butyl ester is typically cleaved under acid-mediated conditions to generate the corresponding carboxylic acid for subsequent coupling. The resulting carboxylic acid can be activated with carbodiimide or uronium-type reagents for amide formation with amine-containing partners under controlled conditions. Suitable solvents include polar aprotic media, and reactions are generally performed under inert atmosphere to minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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