Mal-amido-PEG16-acid
Cat No.: BP-502108
4.5 
Mal-amido-PEG16-acid is a heterobifunctional polyethylene glycol linker featuring a maleimide (Mal) amide handle and a terminal carboxylic acid, separated by an extended PEG chain that provides hydrophilicity and conformational flexibility. The maleimide moiety is designed to undergo selective Michael-type addition with thiol-containing nucleophiles (for example, cysteine residues or thiol-functionalized ligands), enabling stable thioether conjugation under standard bioconjugation conditions. The PEG spacer length supports reduced steric hindrance and improved aqueous solubility, which is advantageous when assembling PROTACs that must simultaneously engage a target-binding ligand and an E3 ligase recruiter. In targeted protein degradation research, this linker serves as a modular “bridge” that can be attached to one component via thiol chemistry and then coupled through the terminal acid to the complementary moiety, facilitating systematic optimization of linker geometry, solvation, and degradation potency.
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* For research and manufacturing use only. Not for human or clinical use.
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Mal-amido-PEG16-acid is a polyethylene glycol (PEG)-based linker designed for constructing PROTACs and other bifunctional degraders. Its Mal-amide handle enables reliable conjugation to ligand-bearing nucleophiles, while the PEG spacer promotes favorable solubility, conformational flexibility, and productive ternary-complex formation. The acid terminus provides a convenient functional handle for downstream coupling strategies. The detailed structural and reactivity considerations for using this linker are provided below.
Structure: This linker combines a PEG chain with an amide linkage and a maleimide-derived functional motif, together with a terminal carboxylic acid. It contains stable amide and ether linkages, plus a reactive maleimide electrophile suited to selective bioconjugation. The PEG segment imparts hydrophilicity and flexible spacing.
Reactivity: The maleimide functionality is typically used for nucleophilic addition reactions with thiols under mild, aqueous-compatible conditions, forming a stable thioether linkage. For PROTAC assembly, the linker is generally reacted with a ligand bearing a compatible thiol (or generated in situ) while controlling pH to favor thiol reactivity and minimize side reactions. Common solvents include buffered aqueous mixtures or polar organic/aqueous blends; bases or catalysts are chosen to support thiol availability.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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