Mal-PEG24-acid
Cat No.: BP-502075
4.5 
Mal-PEG24-acid is a maleimide-terminated polyethylene glycol linker bearing a terminal carboxylic acid, designed for stable, site-selective conjugation in targeted protein degradation constructs. The maleimide group enables chemoselective coupling to thiol-containing ligands (for example, cysteine residues on proteins or thiol-functionalized warheads) via a Michael-type addition, while the PEG chain provides a long, flexible spacer that reduces steric interference and can improve solubility and effective proximity between the recruited binder and the E3 ligase engagement module. The terminal carboxylic acid offers a convenient handle for further derivatization, such as amide coupling or salt formation, facilitating modular PROTAC synthesis and optimization. In PROTAC research, this linker architecture supports efficient assembly and tuning of linker length and hydrophilicity, which are key determinants of ternary complex formation and degradation potency.
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* For research and manufacturing use only. Not for human or clinical use.
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Mal-PEG24-acid is a maleimide-terminated polyethylene glycol (PEG) linker designed for versatile conjugation in targeted protein degradation workflows. Its maleimide functionality enables efficient coupling to thiol-bearing ligands, while the PEG spacer supports solubility and flexible presentation of the recruited binding moiety. This product is commonly used to assemble PROTAC constructs by connecting an E3 ligase binder to a target-binding ligand through a stable thioether linkage. The following sections describe the linker’s structural features and practical reactivity considerations in detail below.
Structure: Mal-PEG24-acid comprises a maleimide electrophile attached to a long-chain PEG segment terminating in a carboxylic acid. It contains an unsaturated maleimide ring capable of Michael-type addition, ether linkages within the PEG backbone, and a terminal acid for handle-based derivatization. Overall, it is flexible and PEG-rich, promoting aqueous compatibility.
Reactivity: The maleimide group reacts with thiols under mild, near-neutral aqueous conditions to form a thioether via Michael addition, typically requiring fresh thiol-containing partners and avoidance of strong nucleophiles that can compete with the maleimide. Coupling is commonly performed in buffered aqueous media with controlled pH and temperature, followed by purification to remove excess thiol reagent. The terminal carboxylic acid can be used for subsequent amide or ester formation using standard coupling chemistries with appropriate activating reagents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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