Methyl-PEG3-Ald
CAS No.: 141981-62-6
Cat No.: BP-501034
4.5 
Methyl-PEG3-Ald is a short, methyl-capped polyethylene glycol linker bearing an aldehyde functional group, providing a flexible, water-compatible chain of three ethylene glycol units terminated for chemical conjugation. In PROTAC and targeted protein degradation workflows, PEG linkers are widely used to tune the spatial relationship and conformational freedom between a ligand for the target protein and a ligand for the E3 ubiquitin ligase, often improving productive ternary complex formation and reducing steric mismatch. The aldehyde handle enables straightforward attachment to amine-containing partners via reductive amination to form a stable secondary amine, allowing researchers to incorporate this linker into larger bifunctional constructs while maintaining aqueous solubility and minimizing aggregation. This product is valuable for systematic linker optimization studies, where varying linker length, hydrophilicity, and attachment chemistry can be critical determinants of degradation potency and selectivity.
Structure of 141981-62-6
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This Methyl-PEG3-Ald linker is designed to support PROTAC assembly by providing a polyethylene glycol spacer terminated with an aldehyde handle for selective conjugation. Its flexible, hydrophilic PEG character can help tune linker solubility, reduce nonspecific interactions, and improve the effective spatial relationship between targeting ligands and the recruited E3 ligase moiety. The aldehyde functionality enables widely used carbonyl-based coupling strategies, and the detailed structural and reaction considerations are provided below.
Structure: The linker comprises a methyl-capped, short polyethylene glycol chain incorporating an aldehyde at the terminus. It contains ether linkages typical of PEG, a terminal carbonyl group, and a conjugation-ready aldehyde carbon. Overall, it is expected to be water-compatible and conformationally flexible.
Reactivity: The aldehyde can participate in carbonyl chemistry for PROTAC construction, most commonly forming reversible imine (Schiff base) intermediates with primary amines or enabling reductive amination workflows. Typical approaches rely on mild, aqueous or mixed aqueous/organic conditions, controlled pH to favor imine formation, and subsequent reduction to stabilize the linkage. Selection of compatible catalysts/reducing agents and solvent systems should follow established reductive amination or carbonyl–amine coupling protocols to maintain ligand integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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