Methyltetrazine-PEG24-NH-Boc
Cat No.: BP-501882
Purity: 98%
4.5 
Methyltetrazine-PEG24-NH-Boc is a heterobifunctional PROTAC linker built on a long, flexible polyethylene glycol chain terminated with a methyltetrazine moiety and a Boc-protected amine. Structurally, it combines a tetrazine handle for rapid inverse-electron-demand Diels–Alder ligation with a protected conjugation site, enabling controlled coupling to targeting ligands or other PROTAC modules under standard amide-forming or deprotection workflows. In targeted protein degradation designs, the methyltetrazine group serves as a bioorthogonal “reaction handle” to assemble multi-component constructs by covalently linking partners bearing compatible strained dienes, thereby improving modularity and reducing reliance on harsh chemistries. The PEG24 spacer provides enhanced solubility and conformational flexibility, which can help maintain productive ternary complex formation and reduce steric mismatch between the recruiter and target-binding elements. This linker is valuable for researchers optimizing assembly strategies and physicochemical properties of PEGylated PROTACs for mechanistic studies and structure–activity relationship exploration.
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* For research and manufacturing use only. Not for human or clinical use.
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Methyltetrazine-PEG24-NH-Boc is a PEG-based PROTAC linker designed to couple a methyltetrazine functional handle with a protected amine for modular assembly. Its flexible polyethylene glycol segment supports productive ternary complex formation by improving reach and reducing steric constraints, while the methyltetrazine motif enables bioorthogonal conjugation strategies commonly used in targeted protein degradation workflows. The protected amine further facilitates controlled stepwise synthesis. Detailed structural and reactivity considerations are provided below.
Structure: The linker combines a methyltetrazine heteroaromatic moiety with a long, flexible PEG chain and a Boc-protected amino terminus. It contains aromatic nitrogen-rich functionality, ether linkages within the PEG backbone, and carbamate protection at the amine, yielding a polar, water-compatible scaffold for solubilizing PROTAC intermediates.
Reactivity: Methyltetrazines are typically employed in inverse-electron-demand Diels–Alder conjugation with strained dienes (commonly trans-cyclooctene derivatives) under mild, aqueous-compatible conditions. The Boc group supports orthogonal synthesis by allowing deprotection with standard acid reagents to reveal the free amine for subsequent coupling to warheads or handles. Solvent choice and order of operations should preserve tetrazine integrity and maintain compatibility with the chosen diene partner.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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