mPEG16-amine
CAS No.: 907577-50-8
Cat No.: BP-501667
Purity: >95%
4.5 
mPEG16-amine is a methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal primary amine, providing a flexible, hydrophilic chain that can be used as a conjugation handle in targeted protein degradation and related bioconjugation workflows. Structurally, it consists of a linear PEG segment of defined average length terminated at one end by methoxy and at the other by an amine, enabling straightforward coupling to activated carboxyl groups, NHS-esters, aldehydes, or other electrophiles used to connect PROTAC ligands, linkers, or solubilizing motifs. In PROTAC design, this amine-functional PEG can serve to tune physicochemical properties such as aqueous solubility and reduced aggregation, while also positioning attachment points to help maintain productive geometry between the E3 ligase binder and the target-binding moiety. Its value for research lies in facilitating synthesis of well-behaved conjugates and improving handling of PROTAC intermediates and final constructs during biochemical evaluation.
Structure of 907577-50-8
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mPEG16-amine is an amine-terminated methoxy poly(ethylene glycol) building block designed for constructing PROTACs and related targeted degradation conjugates. Its ether-rich, flexible PEG backbone can improve solubility and provide a convenient handle for coupling to ligands while maintaining linker flexibility for ternary complex formation. The subsequent points describe its structural attributes and practical reactivity considerations for PROTAC assembly.
Structure: mPEG16-amine contains a methoxy-terminated poly(ethylene glycol) chain bearing a terminal primary amine. The repeating ether units confer flexibility, hydrophilicity, and chemical stability, while the terminal C–N bond enables functional conjugation. Overall, it behaves as a PEG-based, water-compatible linker with a reactive amino group.
Reactivity: The terminal primary amine supports standard amide or urea-forming coupling strategies commonly used in PROTAC synthesis. Suitable approaches include reacting with activated carboxylic acids (e.g., NHS- or HATU-type esters) or isocyanates under mild base/neutral conditions. PEG amines typically couple efficiently in polar aprotic solvents such as DMF or DMSO, with aqueous co-solvents often improving solubility; reaction monitoring by LC or NMR is recommended.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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