Ms-PEG12-Boc
Cat No.: BP-501823
4.5 
Ms-PEG12-Boc is a methanesulfonate (mesylate)–activated polyethylene glycol linker bearing a tert-butyl ester-protected carboxyl group, providing a flexible, hydrophilic chain length suitable for PROTAC and related targeted protein degradation constructs. Structurally, it combines a PEG spacer that can reduce steric constraints and improve solubility with a leaving-group handle that enables efficient nucleophilic substitution, allowing attachment to nucleophile-bearing ligands or intermediates under standard organic conditions. In PROTAC design, the PEG segment serves as a molecular “spacer” that tunes the effective distance and orientation between the target-binding moiety and the E3 ligase recruiter, thereby facilitating formation of the ternary complex and supporting productive ubiquitination. The tert-butyl ester protects the carboxyl group and can be removed under suitable conditions to reveal a carboxylic acid for subsequent coupling steps. This linker is valuable for researchers seeking modular, stepwise synthesis of degraders with improved handling properties and adjustable linker geometry for structure–activity optimization.
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* For research and manufacturing use only. Not for human or clinical use.
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Ms-PEG12-Boc is a bifunctional polyethylene glycol (PEG)-based PROTAC linker building block designed to combine a tert-butyl ester-protected carboxyl handle with a mesylate (Ms) leaving group for modular coupling workflows. Its PEG spacer promotes solubility and provides linker flexibility for modular conjugation workflows. The mesylate enables straightforward substitution chemistry, making it suitable for constructing PROTACs where modular synthesis and reliable functional-group reactivity are required; detailed structural and reactivity guidance follows below.
Structure: The linker contains a PEG repeating unit that provides a hydrophilic, flexible scaffold and a terminal mesylate group for leaving-group activation. A tert-butyl ester-protected carboxyl handle is present to support controlled deprotection and subsequent conjugation. The molecule features ether linkages along the PEG chain and sulfonate ester functionality at the mesylate terminus.
Reactivity: The mesylate is well suited for nucleophilic substitution under conditions that preserve PEG integrity and prevent side reactions. Coupling is typically achieved by reacting the activated mesylate with an appropriate nucleophile (such as an amine or other nucleophilic group) to form a new C–N or related bond, following an SN2-type displacement principle. Common approaches use polar aprotic solvents and base systems compatible with PEG and the tert-butyl ester, with acid-mediated ester cleavage performed when the carboxylic acid is required for the next synthetic step.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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