N-Boc-PEG36-alcohol
Cat No.: BP-501951
4.5 
N-Boc-PEG36-alcohol is a polyethylene glycol (PEG) linker bearing a terminal hydroxyl group and an N-Boc-protected end group, providing a long, flexible hydrophilic spacer for PROTAC and targeted protein degradation constructs. The extended PEG chain length and ether-rich backbone confer conformational freedom and aqueous solubility, which can help reduce steric interference between the ligand-binding moieties and the recruited E3 ligase or target-binding ligand. The terminal alcohol enables straightforward chemical functionalization (for example, conversion to activated esters or ethers) to connect the linker to other PROTAC components, while the Boc group offers a protected handle that can be removed under controlled conditions to reveal an amine for subsequent coupling. In targeted degradation research, such PEG-based linkers are valuable for tuning linker length, flexibility, and physicochemical properties, thereby supporting systematic optimization of ternary complex formation and cellular activity.
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* For research and manufacturing use only. Not for human or clinical use.
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N-Boc-PEG36-alcohol is a PEG-based linker building block designed for constructing PROTACs and related targeted protein degradation conjugates through reliable, modular functionalization. Its polyethylene glycol spacer provides conformational flexibility and improved solubility, while the protected alcohol handle enables controlled downstream coupling to ligands. The Boc-protection strategy supports stepwise synthesis and purification, facilitating assembly of multicomponent degraders. Detailed structure and reactivity guidance are provided below.
Structure: This molecule combines a long polyethylene glycol chain with terminal alcohol functionality and a Boc-protected group. It contains ether linkages typical of PEG, plus carbamate-related motifs from Boc protection, yielding a flexible, hydrophilic scaffold with hydrogen-bonding capacity.
Reactivity: The terminal alcohol can be converted into activated derivatives for ether or ester-forming couplings to ligand-bearing electrophiles or nucleophiles under standard organic synthesis conditions. Boc protection supports selective deprotection strategies to expose reactive sites without disturbing the PEG ether backbone. Common approaches include alcohol activation and subsequent nucleophilic substitution, using appropriate bases and coupling reagents in compatible polar solvents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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