N-Me-N-bis(PEG4-acid)
CAS No.: 2055014-77-0
Cat No.: BP-501438
4.5 
N-Me-N-bis(PEG4-acid) is a polyethylene glycol–based PROTAC linker building block featuring a central N-methyl tertiary amine that is connected to two PEG4-acid arms, providing a symmetric, hydrophilic, and conformationally flexible spacer. The PEG segments act as solubilizing and distance-regulating elements, helping to position the two functional ends of a PROTAC for productive ternary complex formation with a target protein and an E3 ligase ligand. In linker design, such PEGylated acid motifs are commonly used to support conjugation strategies (e.g., amide coupling to carboxyl-reactive or amine-reactive partners) while maintaining aqueous compatibility and reducing nonspecific hydrophobic interactions. This compound is valuable for targeted protein degradation research where linker length, flexibility, and polarity strongly influence binding geometry, degradation potency, and experimental tractability across a range of PROTAC architectures.
Structure of 2055014-77-0
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This PROTAC linker, N-Me-N-bis(PEG4-acid), is designed to connect protein-binding ligands while providing a hydrophilic, flexible spacer that can improve conjugation efficiency and maintain productive ternary-complex formation. Its PEG-based architecture supports aqueous compatibility and can help tune linker length and solvation during targeted protein degradation workflows. The following points describe the structure and reactivity considerations in more detail.
Structure: The linker contains a tertiary N-methylated amine core bearing two PEG-derived acid termini. It features ether-rich PEG segments that confer hydrophilicity, along with carboxylic acid functional groups suitable for amide or ester formation. The molecule is rich in polar heteroatoms and supports conformational flexibility.
Reactivity: The carboxylic acids enable standard PROTAC assembly via coupling to ligand amines or alcohols using peptide-coupling chemistries. Typical approaches use carbodiimide-based activators with coupling additives, or activated ester intermediates, in polar aprotic solvents under controlled pH to favor amide bond formation. Mechanistically, activation of the acid followed by nucleophilic acyl substitution yields stable linker-ligand conjugates suitable for downstream degradation studies.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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