NH2-PEG6-CH2COOtBu
CAS No.: 297162-50-6
Cat No.: BP-501646
Purity: ≥95%
4.5 
NH2-PEG6-CH2COOtBu is a polyethylene glycol–based linker building block featuring a terminal primary amine for bioconjugation, a PEG chain of six ethylene glycol units to provide aqueous solubility and conformational flexibility, and a protected carboxylate end group (tBu ester) suitable for subsequent coupling chemistry. In PROTAC and targeted protein degradation workflows, such PEG linkers are commonly used to spatially separate the ligand-binding moieties, reduce steric clashes, and tune the effective geometry that governs formation of the ternary complex between an E3 ligase ligand and the target-binding ligand. The PEG segment can also mitigate nonspecific aggregation and improve handling in aqueous buffers, while the protected carboxylate enables controlled functionalization into amide or ester linkages during synthesis. This compound is therefore valuable for constructing modular, water-compatible PROTAC architectures where linker length and attachment chemistry must be precisely engineered to optimize degradation performance.
Structure of 297162-50-6
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This PEG-based linker is designed to connect a ligand to an E3-recruiting or target-binding module in PROTAC architectures, providing a flexible, water-compatible spacer that can improve effective intramolecular reach and productive ternary complex formation. Its ether-rich poly(ethylene glycol) character helps modulate solubility and reduces steric constraints around the conjugation sites. The structure and reactivity considerations for constructing PROTACs with this linker are described in detail below.
Structure: The linker contains an amine-terminated polyethylene glycol segment and a protected carboxylate functionality, featuring ether linkages along the PEG chain and an aliphatic methylene spacer adjacent to the ester. The t-butyl ester masks the carboxylic acid during coupling, while the terminal amine enables subsequent functionalization.
Reactivity: For PROTAC synthesis, the protected carboxylate is typically deprotected under standard ester-hydrolysis conditions to reveal a carboxylic acid for amide or other acyl coupling. The terminal primary amine can be used for carbamate or amide bond formation using activated carboxylic acid derivatives. Common approaches employ coupling reagents for amide formation in polar organic solvents, with base to promote nucleophilic acyl substitution.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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