PEG2-Cl
CAS No.: 78925-46-9
Cat No.: BP-501627
4.5 
PEG2-Cl is a short, polyethylene glycol–based chloroalkyl linker designed for PROTAC and targeted protein degradation workflows that require controlled, flexible spacing between functional modules. Structurally, it consists of a two–ethylene glycol unit chain terminated with a reactive chloride, providing a hydrophilic spacer that can reduce steric interference and help tune the effective distance and orientation between the ligand-binding moiety and the recruiter or warhead. In PROTAC architectures, such linkers are commonly used to enable covalent conjugation to nucleophilic groups on partner ligands (for example, via substitution reactions with amines or other nucleophiles), thereby assembling bifunctional degraders with reproducible connectivity. Its PEG character can also improve aqueous solubility and mitigate nonspecific hydrophobic interactions, which is advantageous for maintaining degrader performance in biochemical assays. Overall, PEG2-Cl is a practical building block for constructing linker-defined PROTACs where precise attachment chemistry and modest flexibility are required.
Structure of 78925-46-9
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PEG2-Cl is a bifunctional polyethylene glycol-based chloroalkyl linker designed to support PROTAC assembly by enabling efficient conjugation to ligands through nucleophilic substitution. Its PEG character provides conformational flexibility and improved solubility, while the reactive chloro group serves as a handle for controlled attachment steps. This linker is well suited for constructing targeted protein degradation molecules, and the following points describe its structure and practical reactivity considerations in detail.
Structure: PEG2-Cl features an ethylene glycol oligomer motif terminated with a chlorinated alkyl electrophile. The linker contains ether linkages along the PEG chain and a terminal C–Cl bond, offering a flexible, hydrophilic scaffold that can present attachment points with reduced steric constraints.
Reactivity: The chloroalkyl moiety is typically functionalized via nucleophilic substitution with ligand-derived nucleophiles such as amines or thiols under base-mediated conditions. Common approaches use polar aprotic solvents to promote substitution and minimize side reactions, with reaction temperature and base choice tuned to preserve sensitive functional groups. Mechanistically, the process proceeds through an SN-type pathway or related substitution behavior, depending on substrate electronics and conditions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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